Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | NMT1 | P30419 | 2/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.31 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24122038 | 0.80 | ADORA2A (0.42) | ADORA2AADORA2B | |
| SCHEMBL27192311 | 0.77 | ADORA2A (0.39) | ADORA2AADORA2BNMT1MAPK8 | |
| SCHEMBL27192302 | 0.77 | ADORA2A (0.44) | ADORA2AADORA2B | |
| SCHEMBL31298625 | 0.77 | SSTR4 (0.33) | MAPK8 | |
| SCHEMBL13106267 | 0.73 | ADORA2A (0.44) | ADORA2AADORA2BNMT1MAPK8MAPK9 | |
| SCHEMBL13106312 | 0.73 | ADORA2A (0.44) | ADORA2AADORA2BNMT1MAPK8MAPK9 | |
| SCHEMBL13106244 | 0.73 | SSTR4 (0.40) | ADORA2AADORA2B | |
| SCHEMBL13106253 | 0.72 | NMT1 (0.49) | ADORA2AADORA2BNMT1MAPK8MAPK9 | |
| SCHEMBL13106308 | 0.70 | ADORA2A (0.41) | ADORA2AADORA2BNMT1MAPK8MAPK9 | |
| SCHEMBL26236069 | 0.68 | KDM4E (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3710428-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | Calico Life Sciences LLC (US) | 2020-09-23 | — | — | EP | disclosed |