Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 13/20 | 0.47 |
| ▸ | BAD | Q92934 | 8/20 | 0.45 |
| ▸ | BCL2 | P10415 | 4/20 | 0.45 |
| ▸ | BCL2L1 | Q07817 | 6/20 | 0.45 |
| ▸ | PMAIP1 | Q13794 | 1/20 | 0.43 |
| ▸ | EEF2K | O00418 | 1/20 | 0.43 |
| ▸ | MARK3 | P27448 | 1/20 | 0.43 |
| ▸ | AXL | P30530 | 1/20 | 0.43 |
| ▸ | BCL6 | P41182 | 1/20 | 0.43 |
| ▸ | NEK4 | P51957 | 1/20 | 0.43 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.43 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.43 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.43 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.43 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.43 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.43 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.43 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.43 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22436856 | 0.94 | MCL1 (0.53) | MCL1BADBCL2BCL2L1EEF2K | |
| SCHEMBL22437385 | 0.94 | BAD (0.47) | MCL1BADBCL2BCL2L1PMAIP1 | |
| SCHEMBL22437444 | 0.93 | MCL1 (0.47) | MCL1BADBCL2BCL2L1PMAIP1 | |
| SCHEMBL23753198 | 0.89 | BAD (0.51) | MCL1BADBCL2BCL2L1PMAIP1 | |
| SCHEMBL22436816 | 0.87 | MCL1 (0.53) | MCL1BADBCL2BCL2L1EEF2K | |
| SCHEMBL22436877 | 0.87 | MCL1 (0.53) | MCL1BADBCL2BCL2L1EEF2K | |
| SCHEMBL22437414 | 0.87 | BAD (0.47) | MCL1BADBCL2BCL2L1PMAIP1 | |
| SCHEMBL22437495 | 0.86 | MCL1 (0.57) | MCL1BADBCL2BCL2L1EEF2K | |
| SCHEMBL24745108 | 0.86 | MCL1 (0.56) | MCL1BADBCL2BCL2L1PMAIP1 | |
| SCHEMBL30000272 | 0.86 | MCL1 (0.56) | MCL1BADBCL2BCL2L1PMAIP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11478451-B1 | Macrocyclic chlorine substituted indole derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 2022-10-25 | — | — | US | disclosed |
| US-11478451-B1 | Macrocyclic chlorine substituted indole derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 2022-10-25 | — | — | US | disclosed |
| EP-3710448-A1 | MACROCYCLIC CHLORINE SUBSTITUTED INDOLE DERIVATIVES | Bayer Aktiengesellschaft (DE) | 2020-09-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11478451-B1 | Macrocyclic chlorine substituted indole derivatives | CCNT2, CCNL2, CCND2 | MCL1 26/4885BAD 333/4885BCL2 430/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.