SCHEMBL22439747

SCHEMBL22439747

O=C(O)C(O)(Cn1cncn1)c1ccccc1Oc1ccc(Cl)cc1

nearest known ligand 0.46

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.46
HSP90AA1 P07900 2/20 0.43
CYP3A4 P08684 3/20 0.42
ALDH1A1 P00352 2/20 0.42
MAPT P10636 2/20 0.39
HTT P42858 2/20 0.39
LMNA P02545 2/20 0.38
TSHR P16473 1/20 0.38
CYP19A1 P11511 3/20 0.37
PPARA Q07869 2/20 0.37
CYP2C9 P11712 1/20 0.37
CYP11B1 P15538 1/20 0.37
CYP11B2 P19099 1/20 0.37
CYP2C19 P33261 1/20 0.37
ADRA1A P35348 1/20 0.37
CYP51A1 Q16850 1/20 0.37
KDM4E B2RXH2 1/20 0.36
PPARG P37231 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22407115 0.89 KMT2A (0.43) KMT2AHSP90AA1CYP3A4ALDH1A1MAPT
SCHEMBL27952568 0.84 CYP3A4 (0.49) KMT2AHSP90AA1CYP3A4ALDH1A1MAPT
SCHEMBL22439708 0.83 KMT2A (0.53) KMT2AHSP90AA1CYP3A4ALDH1A1MAPT
SCHEMBL22406966 0.83 KMT2A (0.43) KMT2AHSP90AA1CYP3A4ALDH1A1MAPT
SCHEMBL30089753 0.83 KMT2A (0.43) KMT2AHSP90AA1CYP3A4ALDH1A1MAPT
SCHEMBL23925318 0.83 KMT2A (0.43) KMT2AHSP90AA1CYP3A4ALDH1A1MAPT
SCHEMBL28922872 0.83 KMT2A (0.43) KMT2AHSP90AA1CYP3A4ALDH1A1MAPT
SCHEMBL22439724 0.83 KMT2A (0.42) KMT2AHSP90AA1CYP3A4ALDH1A1MAPT
SCHEMBL22439751 0.81 KMT2A (0.43) KMT2AHSP90AA1CYP3A4ALDH1A1MAPT
SCHEMBL22439746 0.78 HSP90AA1 (0.57) KMT2AHSP90AA1ALDH1A1MAPTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3712135-A1 AZOLE DERIVATIVE, INTERMEDIATE COMPOUND, METHOD FOR PRODUCING AZOLE DERIVATIVE, AGENT FOR AGRICULTURAL AND HORTICULTURAL USE, AND MATERIAL PROTECTION AGENT FOR INDUSTRIAL USE Kureha Corporation (JP) 2020-09-23 EP disclosed