Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 9/20 | 1.00 |
| ▸ | ESR2 | Q92731 | 8/20 | 1.00 |
| ▸ | LMNA | P02545 | 4/20 | 1.00 |
| ▸ | MEN1 | O00255 | 3/20 | 1.00 |
| ▸ | MAPT | P10636 | 3/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 3/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 1.00 |
| ▸ | GAA | P10253 | 2/20 | 1.00 |
| ▸ | G6PD | P11413 | 2/20 | 1.00 |
| ▸ | PKM | P14618 | 2/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 2/20 | 1.00 |
| ▸ | MPI | P34949 | 1/20 | 1.00 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.80 |
| ▸ | STS | P08842 | 2/20 | 0.73 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.66 |
| ▸ | TSHR | P16473 | 2/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.66 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29506781 | 1.00 | ESR1 (1.00) | ESR1ESR2LMNAMEN1MAPT | |
| SCHEMBL12027477 | 1.00 | ESR1 (1.00) | ESR1ESR2LMNAMEN1MAPT | |
| SCHEMBL13123059 | 1.00 | ESR1 (1.00) | ESR1ESR2LMNAMEN1MAPT | |
| SCHEMBL6009933 | 1.00 | ESR1 (1.00) | ESR1ESR2LMNAMEN1MAPT | |
| SCHEMBL224398 | 1.00 | ESR1 (1.00) | ESR1ESR2LMNAMEN1MAPT | |
| SCHEMBL11490000 | 0.90 | ESR1 (0.82) | ESR1ESR2LMNAMEN1MAPT | |
| SCHEMBL5526011 | 0.90 | ESR1 (0.82) | ESR1ESR2LMNAMEN1MAPT | |
| SCHEMBL5497284 | 0.90 | ESR1 (0.82) | ESR1ESR2LMNAMEN1MAPT | |
| SCHEMBL5497281 | 0.90 | ESR1 (0.82) | ESR1ESR2LMNAMEN1MAPT | |
| SCHEMBL5526013 | 0.90 | ESR1 (0.82) | ESR1ESR2LMNAMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 187 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210379087-A1 | COMPOSITIONS FOR THE ELIMINATION OF SENESCENT CELLS | MEDIZINISCHE UNIVERSITÄT WIEN (AT) | 2021-12-09 | — | — | US | claimed |
| EP-3643305-A1 | COMPOSITIONS FOR THE ELIMINATION OF SENESCENT CELLS | Universität für Bodenkultur Wien (AT) | 2020-04-29 | — | — | EP | claimed |
| US-7951890-B2 | Using epichlorohydrin to form gel; pulverization; mixing with buffer solution and hydrolases; stirring; centrifuging | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2011-05-31 | — | — | US | claimed |
| US-20080207931-A1 | Solid-Phase Extraction Method of Steroid Hormones by Entrapped Beta-Cyclodextrin Polymers | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2008-08-28 | — | — | US | claimed |
| CN-100406015-C | Estradiol metabolites for the treatment of pulmonary hypertension | UNIV PITTSBURGH (US) | 2008-07-30 | — | — | CN | claimed |
| US-20080171730-A1 | Administration of estradiol metabolites for the treatment or prevention of obesity, metabolic syndrome, diabetes and vascular and renal disorders | UNIVERSITY OF PITTSBURGH (US) | 2008-07-17 | — | — | US | claimed |
| CN-101056643-A | Long acting injectable crystal formulations of estradiol metabolites and methods of using same | PR PHARMACEUTICALS INC (US) | 2007-10-17 | — | — | CN | claimed |
| EP-1829529-A1 | Controlled release compositions of estradiol metabolites | PR Pharmaceuticals, Inc. (US) | 2007-09-05 | — | — | EP | claimed |
| EP-1418876-A4 | ADMINISTRATION OF ESTRADIOL METABOLITES FOR THE TREATMENT OR PREVENTION OF OBESITY, METABOLIC SYNDROME, DIABETES, AND VASCULAR AND RENAL DISORDERS | UNIV PITTSBURGH (US) | 2007-07-11 | — | — | EP | claimed |
| EP-1507514-B1 | CONTROLLED RELEASE COMPOSITIONS OF ESTRADIOL METABOLITES | PR PHARMACEUTICALS INC (US) | 2007-02-14 | — | — | EP | claimed |
| EP-1549939-A2 | IMPROVEMENTS IN PHARMACEUTICAL DISCOVERY AND DEVELOPMENT | ESA, Inc. (US) | 2005-07-06 | — | — | EP | claimed |
| EP-1507514-A2 | CONTROLLED RELEASE COMPOSITIONS OF ESTRADIOL METABOLITES | PR Pharmaceuticals, Inc. (US) | 2005-02-23 | — | — | EP | claimed |
| CN-1571672-A | Administration of estradiol metabolites for the treatment or prevention of obesity, metabolic syndrome, diabetes, and vascular and renal disorders | UNIV PITTSBURGH (US) | 2005-01-26 | — | — | CN | claimed |
| EP-1418876-A2 | ADMINISTRATION OF ESTRADIOL METABOLITES FOR THE TREATMENT OR PREVENTION OF OBESITY, METABOLIC SYNDROME, DIABETES, AND VASCULAR AND RENAL DISORDERS | UNIVERSITY OF PITTSBURGH (US) | 2004-05-19 | — | — | EP | claimed |
| WO-2003092585-A2 | CONTROLLED RELEASE COMPOSITIONS OF ESTRADIOL METABOLITES | PR PHARMACEUTICALS, INC. (US) | 2003-11-13 | — | — | WO | claimed |
| WO-2003081208-A2 | IMPROVEMENTS IN PHARMACEUTICAL DISCOVERY AND DEVELOPMENT | ESA, INC. (US) | 2003-10-02 | — | — | WO | claimed |
| US-20030050294-A1 | Administration of estradiol metabolites for the treatment or prevention of obesity, metabolic syndrome, diabetes, and vascular and renal disorders | PITTSBURGH, UNIVERSITY OF | 2003-03-13 | — | — | US | claimed |
| WO-2003015704-A2 | ADMINISTRATION OF ESTRADIOL METABOLITES FOR THE TREATMENT OR PREVENTION OF OBESITY, METABOLIC SYNDROME, DIABETES, AND VASCULAR AND RENAL DISORDERS | UNIVERSITY OF PITTSBURGH (US) | 2003-02-27 | — | — | WO | claimed |
| WO-1997040061-A1 | ESTROGEN-PURINE BASE, ESTROGEN-MERCAPTURATE ADDUCTS, AND FLUORESCENT PROBES AND MONOCLONAL ANTIBODIES THEREOF | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) | 1997-10-30 | — | — | WO | claimed |
| US-4937238-A | ADMINISTERING ESTROGEN COMPOUNDS | THE BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) | 1990-06-26 | — | — | US | claimed |