Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 13/20 | 0.58 |
| ▸ | AURKA | O14965 | 2/20 | 0.48 |
| ▸ | ITK | Q08881 | 2/20 | 0.47 |
| ▸ | JAK2 | O60674 | 2/20 | 0.46 |
| ▸ | JAK1 | P23458 | 2/20 | 0.46 |
| ▸ | TTK | P33981 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22445924 | 0.97 | LRRK2 (0.59) | LRRK2AURKAITKJAK2JAK1 | |
| SCHEMBL22453882 | 0.92 | LRRK2 (0.55) | LRRK2 | |
| SCHEMBL22445883 | 0.86 | JAK2 (0.44) | LRRK2JAK2JAK1 | |
| SCHEMBL22445853 | 0.85 | JAK2 (0.43) | LRRK2JAK2JAK1 | |
| SCHEMBL22453880 | 0.83 | LRRK2 (0.52) | LRRK2 | |
| SCHEMBL22445913 | 0.82 | LRRK2 (0.58) | LRRK2ITKJAK2JAK1 | |
| SCHEMBL22445881 | 0.82 | LRRK2 (0.58) | LRRK2AURKAITK | |
| SCHEMBL22445893 | 0.82 | LRRK2 (0.58) | LRRK2AURKAITK | |
| SCHEMBL22445832 | 0.81 | LRRK2 (0.59) | LRRK2ITKJAK2JAK1 | |
| SCHEMBL22445826 | 0.81 | LRRK2 (0.59) | LRRK2AURKAITKJAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020191261-A1 | INDAZOLES AS LRRK2 INHIBITORS | E-SCAPE BIO, INC. (US) | 2020-09-24 | — | — | WO | claimed |
| WO-2020191261-A1 | INDAZOLES AS LRRK2 INHIBITORS | E-SCAPE BIO, INC. (US) | 2020-09-24 | — | — | WO | disclosed |