Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 9/20 | 0.42 |
| ▸ | MAOB | P27338 | 3/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 3/20 | 0.38 |
| ▸ | JAK1 | P23458 | 3/20 | 0.38 |
| ▸ | F11 | P03951 | 1/20 | 0.37 |
| ▸ | ITK | Q08881 | 2/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453952 | 0.86 | LRRK2 (0.53) | LRRK2MAOBMAOAF11 | |
| SCHEMBL22445975 | 0.86 | NAMPT (0.41) | LRRK2MAOBJAK2JAK1F11 | |
| SCHEMBL22445969 | 0.84 | LRRK2 (0.51) | LRRK2MAOBMAOAF11 | |
| SCHEMBL22446036 | 0.84 | LRRK2 (0.49) | LRRK2MAOBMAOAF11 | |
| SCHEMBL22445909 | 0.84 | LRRK2 (0.51) | LRRK2JAK2JAK1ITK | |
| SCHEMBL22445867 | 0.84 | LRRK2 (0.45) | LRRK2MAOBMAOAJAK2JAK1 | |
| SCHEMBL22445817 | 0.83 | LRRK2 (0.44) | LRRK2MAOBMAOAJAK2JAK1 | |
| SCHEMBL22453798 | 0.83 | LRRK2 (0.47) | LRRK2F11ITKPDPK1 | |
| SCHEMBL22454050 | 0.81 | LRRK2 (0.46) | LRRK2 | |
| SCHEMBL22446002 | 0.81 | LRRK2 (0.43) | LRRK2MAOBMAOAJAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020191261-A1 | INDAZOLES AS LRRK2 INHIBITORS | E-SCAPE BIO, INC. (US) | 2020-09-24 | — | — | WO | claimed |
| WO-2020191261-A1 | INDAZOLES AS LRRK2 INHIBITORS | E-SCAPE BIO, INC. (US) | 2020-09-24 | — | — | WO | disclosed |