Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 1/20 | 0.46 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.43 |
| ▸ | PRKCI | P41743 | 3/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | CCNC | P24863 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22448326 | 0.80 | PRKCI (0.49) | CHEK2FLT1NPSR1PRKCINPC1 | |
| SCHEMBL17829983 | 0.79 | PRKCI (0.51) | PRKCI | |
| SCHEMBL12228869 | 0.70 | MEN1 (0.56) | MEN1KMT2APRKCIPDPK1 | |
| SCHEMBL4420538 | 0.68 | KMT2A (0.55) | MEN1KMT2APRKCIPDPK1NPC1 | |
| SCHEMBL4421700 | 0.68 | MEN1 (0.55) | MEN1KMT2ASIRT2SMN1; SMN2PRKCI | |
| SCHEMBL5368863 | 0.68 | S1PR2 (0.56) | CHEK2FLT1LMNASMN1; SMN2NPSR1 | |
| SCHEMBL24927432 | 0.65 | CHEK2 (0.46) | CHEK2FLT1MEN1KMT2ALMNA | |
| SCHEMBL4359385 | 0.65 | HTT (0.83) | MEN1KMT2ALMNASMN1; SMN2NPSR1 | |
| SCHEMBL31089964 | 0.64 | SMN1; SMN2 (0.58) | MEN1KMT2ALMNASMN1; SMN2NPSR1 | |
| SCHEMBL14300973 | 0.64 | HTT (0.59) | KMT2ALMNASMN1; SMN2NPSR1S1PR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3404031-B1 | THIENO[3,2-D]PYRIMIDINES DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) | 2020-09-23 | — | — | EP | disclosed |