Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.51 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.51 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.51 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | TPH1 | P17752 | 4/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15037253 | 1.00 | MAPT (0.55) | MAPTS1PR4S1PR1S1PR5S1PR3 | |
| SCHEMBL22449035 | 0.99 | MAPT (0.54) | MAPTS1PR4S1PR1S1PR5S1PR3 | |
| SCHEMBL15037251 | 0.99 | MAPT (0.54) | MAPTS1PR4S1PR1S1PR5S1PR3 | |
| SCHEMBL22449247 | 0.96 | S1PR4 (0.54) | MAPTS1PR4S1PR1S1PR5S1PR3 | |
| SCHEMBL15037155 | 0.96 | S1PR4 (0.54) | MAPTS1PR4S1PR1S1PR5S1PR3 | |
| SCHEMBL15037252 | 0.93 | S1PR4 (0.52) | MAPTS1PR4S1PR1S1PR5S1PR3 | |
| SCHEMBL15037108 | 0.92 | MAPT (0.48) | MAPTS1PR4S1PR1S1PR5S1PR3 | |
| SCHEMBL22448929 | 0.92 | S1PR4 (0.51) | MAPTS1PR4S1PR1S1PR5S1PR3 | |
| SCHEMBL15037369 | 0.92 | S1PR4 (0.51) | MAPTS1PR4S1PR1S1PR5S1PR3 | |
| SCHEMBL15037370 | 0.92 | S1PR4 (0.51) | MAPTS1PR4S1PR1S1PR5S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2791112-B1 | CARBOXYLIC ACID DERIVATIVES COMPRISING FOUR CYCLES ACTING AS GLP-1 RECEPTOR MODULATORS FOR THERAPY OF DISEASES SUCH AS DIABETES | CELGENE INT II SÀRL (CH) | 2020-09-23 | — | — | EP | disclosed |