Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 18/20 | 0.80 |
| ▸ | JAK1 | P23458 | 4/20 | 0.61 |
| ▸ | AXL | P30530 | 2/20 | 0.61 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.60 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.60 |
| ▸ | MERTK | Q12866 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21412834 | 0.95 | JAK2 (0.84) | JAK2JAK1AXLPIK3CDTYRO3 | |
| SCHEMBL14377767 | 0.95 | JAK2 (0.84) | JAK2JAK1AXLPIK3CDTYRO3 | |
| SCHEMBL29379586 | 0.95 | JAK2 (0.84) | JAK2JAK1AXLPIK3CDTYRO3 | |
| SCHEMBL14376756 | 0.95 | JAK2 (0.84) | JAK2JAK1AXLPIK3CDTYRO3 | |
| SCHEMBL16532750 | 0.93 | JAK2 (0.80) | JAK2JAK1AXLPIK3CDTYRO3 | |
| SCHEMBL22622522 | 0.93 | JAK2 (0.79) | JAK2JAK1AXLPIK3CDTYRO3 | |
| SCHEMBL22449884 | 0.93 | JAK2 (0.79) | JAK2JAK1AXLPIK3CDTYRO3 | |
| SCHEMBL14377572 | 0.90 | JAK2 (0.82) | JAK2JAK1AXL | |
| SCHEMBL21799144 | 0.90 | JAK2 (0.82) | JAK2JAK1AXL | |
| SCHEMBL14377481 | 0.90 | JAK2 (0.82) | JAK2JAK1AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3129021-B1 | TREATMENT OF B-CELL MALIGNANCIES BY A COMBINATION JAK AND PI3K INHIBITOR | INCYTE CORP (US) | 2020-09-23 | — | — | EP | disclosed |