Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 18/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | FGFR2 | P21802 | 9/20 | 0.40 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.38 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.38 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22451152 | 0.90 | FGFR4 (0.41) | FGFR4FGFR1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL21386627 | 0.90 | FGFR4 (0.41) | FGFR4FGFR1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL21756532 | 0.86 | FGFR4 (0.44) | FGFR4FGFR1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL23135910 | 0.86 | FGFR4 (0.46) | FGFR4FGFR1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL21386631 | 0.86 | FGFR4 (0.46) | FGFR4FGFR1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL21386630 | 0.86 | FGFR4 (0.46) | FGFR4FGFR1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL21756533 | 0.85 | FGFR4 (0.44) | FGFR4FGFR1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL21386628 | 0.85 | FGFR4 (0.62) | FGFR4FGFR1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL23135909 | 0.85 | FGFR4 (0.62) | FGFR4FGFR1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL21386615 | 0.85 | FGFR4 (0.62) | FGFR4FGFR1CYP2C9CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3712146-A1 | SALT FORM AND CRYSTAL FORM OF COMPOUND AS FGFR4 INHIBITOR AND PREPARATION METHOD THEREOF | Guangdong Zhongsheng Pharmaceutical Co., Ltd (CN) | 2020-09-23 | — | — | EP | disclosed |