Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H3 | Q13133 | 20/20 | 0.98 |
| ▸ | NR1H2 | P55055 | 19/20 | 0.98 |
| ▸ | RXRA | P19793 | 2/20 | 0.76 |
| ▸ | MEN1 | O00255 | 1/20 | 0.76 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.76 |
| ▸ | MAPT | P10636 | 1/20 | 0.76 |
| ▸ | VHL | P40337 | 1/20 | 0.76 |
| ▸ | RECQL | P46063 | 1/20 | 0.76 |
| ▸ | BLM | P54132 | 1/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3982481 | 0.99 | NR1H3 (1.00) | NR1H3NR1H2RXRAMEN1NR1I2 | |
| SCHEMBL3982484 | 0.99 | NR1H3 (1.00) | NR1H3NR1H2RXRAMEN1NR1I2 | |
| SCHEMBL3983081 | 0.99 | NR1H3 (1.00) | NR1H3NR1H2RXRAMEN1NR1I2 | |
| Hydrochloric Acid SCHEMBL3979095 | 0.98 | NR1H3 (0.98) | NR1H3NR1H2RXRAMEN1NR1I2 | |
| Hydrochloric Acid SCHEMBL3984789 | 0.98 | NR1H3 (0.98) | NR1H3NR1H2RXRAMEN1NR1I2 | |
| Hydrochloric Acid SCHEMBL3979089 | 0.98 | NR1H3 (0.98) | NR1H3NR1H2RXRAMEN1NR1I2 | |
| SCHEMBL4953150 | 0.93 | NR1H3 (0.89) | NR1H3NR1H2RXRAMEN1NR1I2 | |
| SCHEMBL4949969 | 0.93 | NR1H3 (0.89) | NR1H3NR1H2RXRAMEN1NR1I2 | |
| SCHEMBL4949961 | 0.93 | NR1H3 (0.89) | NR1H3NR1H2RXRAMEN1NR1I2 | |
| Hydrochloric Acid SCHEMBL4949762 | 0.93 | NR1H3 (0.88) | NR1H3NR1H2RXRAMEN1NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1907564-B1 | LXR LIGAND TESTING METHOD | DAIICHI SANKYO CO LTD (JP) | 2013-10-23 | — | — | EP | disclosed |
| US-7989179-B2 | LXR ligand testing method | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2011-08-02 | — | — | US | disclosed |
| US-20090098570-A1 | Lxr ligand testing method | EXELIXIS, INC. | 2009-04-16 | — | — | US | disclosed |