Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 2/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.38 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453312 | 0.95 | SERPINE1 (0.43) | SERPINE1HIF1AEPAS1ALDH1A1CA1 | |
| SCHEMBL22452779 | 0.91 | SERPINE1 (0.39) | SERPINE1SMN1; SMN2AURKAMEN1KMT2A | |
| SCHEMBL22453603 | 0.86 | HIF1A (0.43) | SERPINE1HIF1AEPAS1ALDH1A1SMN1; SMN2 | |
| SCHEMBL22452975 | 0.85 | AURKA (0.36) | SERPINE1HIF1AALDH1A1CA1CA2 | |
| SCHEMBL22453039 | 0.84 | CA1 (0.34) | ALDH1A1CA1CA2SMN1; SMN2AURKA | |
| SCHEMBL22452750 | 0.84 | NPC1 (0.38) | SERPINE1HIF1AEPAS1MEN1POLB | |
| SCHEMBL22452560 | 0.82 | SERPINE1 (0.40) | SERPINE1HIF1AALDH1A1AURKAMEN1 | |
| SCHEMBL22453416 | 0.82 | HIF1A (0.42) | SERPINE1HIF1AEPAS1ALDH1A1SMN1; SMN2 | |
| SCHEMBL22452478 | 0.81 | HIF1A (0.40) | SERPINE1HIF1AEPAS1EPHX2 | |
| SCHEMBL22452684 | 0.80 | HIF1A (0.52) | SERPINE1HIF1AEPAS1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |