Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.53 |
| ▸ | ELANE | P08246 | 1/20 | 0.51 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.51 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.50 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.49 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453766 | 0.95 | HPGD (0.56) | HPGDMAPK10TSHRCYP1A2CYP2D6 | |
| SCHEMBL22453221 | 0.93 | HIF1A (0.51) | HPGDMAPK10TSHRCYP1A2CYP2D6 | |
| SCHEMBL22452577 | 0.93 | HIF1A (0.51) | HPGDMAPK10TSHRCYP1A2CYP2D6 | |
| SCHEMBL22453226 | 0.91 | HIF1A (0.53) | HPGDMAPK10TSHRSERPINE1HIF1A | |
| SCHEMBL22453681 | 0.89 | ELANE (0.56) | HPGDMAPK10TSHRCYP1A2CYP2D6 | |
| SCHEMBL22452503 | 0.89 | MAPT (0.58) | TSHRHIF1AEPAS1EPHX2NPC1 | |
| SCHEMBL22453680 | 0.89 | SERPINE1 (0.53) | HPGDMAPK10TSHRCYP1A2CYP2D6 | |
| SCHEMBL22452488 | 0.88 | SERPINE1 (0.64) | SERPINE1HIF1AEPAS1EPHX2NPC1 | |
| SCHEMBL22453220 | 0.86 | SERPINE1 (0.46) | HPGDMAPK10TSHRCYP1A2CYP2D6 | |
| SCHEMBL22452790 | 0.86 | SERPINE1 (0.51) | HPGDMAPK10TSHRCYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |