Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.72 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.70 |
| ▸ | PDGFRB | P09619 | 10/20 | 0.68 |
| ▸ | CSF1R | P07333 | 1/20 | 0.68 |
| ▸ | KIT | P10721 | 2/20 | 0.67 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.67 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.67 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.67 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.67 |
| ▸ | FLT3 | P36888 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22454334 | 0.99 | KDR (0.70) | KDRPDGFRAPDGFRBCSF1RKIT | |
| SCHEMBL5825213 | 0.88 | PDGFRB (0.76) | KDRPDGFRAPDGFRBCSF1RKIT | |
| SCHEMBL5825206 | 0.86 | PDGFRB (0.67) | KDRPDGFRAPDGFRBCSF1RKIT | |
| SCHEMBL5824465 | 0.85 | KDR (0.73) | KDRPDGFRAPDGFRBCSF1RKIT | |
| SCHEMBL5824658 | 0.85 | KDR (0.73) | KDRPDGFRAPDGFRBCSF1RKIT | |
| SCHEMBL6009208 | 0.84 | KDR (0.83) | KDRPDGFRAPDGFRBCSF1RKIT | |
| SCHEMBL7480612 | 0.83 | KDR (1.00) | KDRPDGFRAPDGFRBCSF1RKIT | |
| SCHEMBL5824362 | 0.83 | KDR (0.81) | KDRPDGFRAPDGFRBCSF1RKIT | |
| SCHEMBL5824681 | 0.82 | KDR (0.73) | KDRPDGFRACSF1RKIT | |
| SCHEMBL24358871 | 0.82 | KDR (0.85) | KDRPDGFRAPDGFRBCSF1RKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3929182-A1 | MULTI-TARGET KINASE INHIBITOR, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND PREPARATION METHOD AND USE THEREOF | Guangzhou Liushun Biotechnology Co., Ltd. (CN) | 2021-12-29 | — | — | EP | disclosed |
| WO-2020186812-A1 | MULTI-TARGET KINASE INHIBITOR, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND PREPARATION METHOD AND USE THEREOF | 广州六顺生物科技股份有限公司 | 2020-09-24 | — | — | WO | disclosed |