Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.70 |
| ▸ | NPC1 | O15118 | 2/20 | 0.70 |
| ▸ | RAB9A | P51151 | 2/20 | 0.70 |
| ▸ | P4HB | P07237 | 1/20 | 0.70 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.70 |
| ▸ | MAPT | P10636 | 3/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | ATM | Q13315 | 2/20 | 0.67 |
| ▸ | MDM4 | O15151 | 1/20 | 0.67 |
| ▸ | JAK2 | O60674 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | XBP1 | P17861 | 1/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.67 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.67 |
| ▸ | MIF | P14174 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | ALPL | P05186 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22822759 | 1.00 | MEN1 (0.70) | MEN1KMT2ANPC1RAB9AP4HB | |
| SCHEMBL22462357 | 1.00 | MEN1 (0.70) | MEN1KMT2ANPC1RAB9AP4HB | |
| SCHEMBL22550784 | 0.90 | KMT2A (0.66) | MEN1KMT2ANPC1RAB9AP4HB | |
| SCHEMBL22529622 | 0.90 | KMT2A (0.66) | MEN1KMT2ANPC1RAB9AP4HB | |
| SCHEMBL22529621 | 0.90 | KMT2A (0.66) | MEN1KMT2ANPC1RAB9AP4HB | |
| SCHEMBL22462354 | 0.89 | MAPT (0.63) | MEN1KMT2ANPC1RAB9AP4HB | |
| SCHEMBL22822875 | 0.89 | MAPT (0.63) | MEN1KMT2ANPC1RAB9AP4HB | |
| SCHEMBL22462353 | 0.89 | MAPT (0.63) | MEN1KMT2ANPC1RAB9AP4HB | |
| SCHEMBL22550767 | 0.83 | MAPT (0.74) | MEN1KMT2ANPC1RAB9AP4HB | |
| SCHEMBL22822756 | 0.81 | LY96 (0.67) | MEN1KMT2ANPC1RAB9AP4HB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3713916-A1 | 3,5-DIARYLIDENYL-N-SUBSTITUTED-PIPERID-4-ONE-DERIVED INHIBITORS OF STAT3 PATHWAY ACITIVTY AND USES THEROF | Kiakos, Konstantinos (AT) | 2020-09-30 | — | — | EP | disclosed |