SCHEMBL22470146

SCHEMBL22470146

COC(=O)N(C[C@@]1(C)CCCN1C(=O)O)C1(c2ccc(F)c(C(F)(F)F)c2)CC1

nearest known ligand 0.61

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
KCNN4 O15554 8/20 0.61
MCHR1 Q99705 6/20 0.34
NOTUM Q6P988 1/20 0.33
OPRM1 P35372 1/20 0.33
OPRL1 P41146 1/20 0.33
SLC6A9 P48067 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22470153 1.00 KCNN4 (0.61) KCNN4MCHR1NOTUMOPRM1OPRL1
SCHEMBL30916773 1.00 KCNN4 (0.61) KCNN4MCHR1NOTUMOPRM1OPRL1
SCHEMBL22470149 1.00 KCNN4 (0.61) KCNN4MCHR1NOTUMOPRM1OPRL1
SCHEMBL29358542 0.89 KCNN4 (0.60) KCNN4MCHR1
SCHEMBL29356961 0.89 KCNN4 (0.60) KCNN4MCHR1
SCHEMBL30916799 0.80 KCNN4 (0.74) KCNN4MCHR1
SCHEMBL29353639 0.79 KCNN4 (0.63) KCNN4MCHR1SLC6A9
SCHEMBL29355252 0.79 KCNN4 (0.63) KCNN4MCHR1SLC6A9
SCHEMBL29353666 0.79 KCNN4 (0.78) KCNN4MCHR1
SCHEMBL22470169 0.78 KCNN4 (0.80) KCNN4MCHR1NOTUM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12006289-B2 Potassium channel inhibitors SANIONA A/S (DK) 2024-06-11 US disclosed
US-20220169602-A1 NOVEL POTASSIUM CHANNEL INHIBITORS SANIONA A/S (DK) 2022-06-02 US disclosed
EP-3941903-A1 NOVEL POTASSIUM CHANNEL INHIBITORS Saniona A/S (DK) 2022-01-26 EP disclosed
WO-2020193419-A1 NOVEL POTASSIUM CHANNEL INHIBITORS SANIONA A/S (DK) 2020-10-01 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220169602-A1 NOVEL POTASSIUM CHANNEL INHIBITORS KCNN2, KCNJ2, KCNN1 KCNN4 57/4885MCHR1 4050/4885NOTUM 4389/4885
US-12006289-B2 Potassium channel inhibitors KCNJ2, KCNN2, KCNN1 KCNN4 48/4885MCHR1 4249/4885NOTUM 3646/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.