Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 11/20 | 0.70 |
| ▸ | RAF1 | P04049 | 11/20 | 0.70 |
| ▸ | KDR | P35968 | 8/20 | 0.70 |
| ▸ | KRAS | P01116 | 7/20 | 0.70 |
| ▸ | ABL1 | P00519 | 4/20 | 0.70 |
| ▸ | ARAF | P10398 | 3/20 | 0.70 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.70 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.70 |
| ▸ | FYN | P06241 | 1/20 | 0.70 |
| ▸ | SRC | P12931 | 1/20 | 0.70 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.70 |
| ▸ | CSK | P41240 | 1/20 | 0.70 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.70 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.70 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.70 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.70 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.70 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.70 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.70 |
| ▸ | MAP3K1 | Q13233 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15269365 | 0.89 | BRAF (0.72) | BRAFRAF1KDRKRASABL1 | |
| SCHEMBL22360887 | 0.89 | BRAF (0.71) | BRAFRAF1KDRKRASABL1 | |
| SCHEMBL16683482 | 0.84 | RAF1 (0.77) | BRAFRAF1KDRKRASABL1 | |
| Ly-3009120 SCHEMBL29479162 | 0.83 | RAF1 (1.00) | BRAFRAF1KDRKRASABL1 | |
| Ly-3009120 SCHEMBL29356086 | 0.83 | RAF1 (1.00) | BRAFRAF1KDRKRASABL1 | |
| Ly-3009120 SCHEMBL15241297 | 0.83 | RAF1 (1.00) | BRAFRAF1KDRKRASABL1 | |
| SCHEMBL16682363 | 0.82 | RAF1 (0.77) | BRAFRAF1KDRKRASABL1 | |
| SCHEMBL16667718 | 0.82 | RAF1 (0.77) | BRAFRAF1KDRKRASABL1 | |
| SCHEMBL16682374 | 0.82 | BRAF (0.64) | BRAFRAF1KDRKRASABL1 | |
| SCHEMBL16667639 | 0.81 | BRAF (0.65) | BRAFRAF1KDRKRASABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10787443-B2 | RAF-degrading conjugate compounds | ZAMBONI CHEM SOLUTIONS INC. (CA) | 2020-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10787443-B2 | RAF-degrading conjugate compounds | BRAF, RAF1, ARAF | BRAF 1/4885RAF1 2/4885KDR 716/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.