Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 8/20 | 0.41 |
| ▸ | BRAF | P15056 | 8/20 | 0.40 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.35 |
| ▸ | MAP3K14 | Q99558 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22360762 | 0.92 | ACVR1 (0.42) | ACVR1BRAFPIK3C3MAP3K14 | |
| SCHEMBL20574013 | 0.91 | ACVR1 (0.42) | ACVR1BRAFPIK3C3MAP3K14 | |
| SCHEMBL2960546 | 0.87 | BRAF (0.53) | ACVR1BRAFMAP3K14 | |
| SCHEMBL2639988 | 0.84 | BRAF (0.44) | ACVR1BRAFMAP3K14 | |
| SCHEMBL29352906 | 0.84 | BRAF (0.44) | ACVR1BRAFMAP3K14 | |
| SCHEMBL20574042 | 0.82 | ACVR1 (0.37) | ACVR1BRAF | |
| SCHEMBL22473738 | 0.81 | BRAF (0.44) | ACVR1BRAFMAP3K14 | |
| SCHEMBL22360766 | 0.81 | ACVR1 (0.41) | ACVR1BRAFPIK3C3MAP3K14 | |
| SCHEMBL22360768 | 0.81 | ACVR1 (0.42) | ACVR1BRAFPIK3C3MAP3K14 | |
| SCHEMBL20574048 | 0.81 | ACVR1 (0.36) | ACVR1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10787443-B2 | RAF-degrading conjugate compounds | ZAMBONI CHEM SOLUTIONS INC. (CA) | 2020-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10787443-B2 | RAF-degrading conjugate compounds | BRAF, RAF1, ARAF | ACVR1 2798/4885BRAF 1/4885PIK3C3 341/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.