Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 20/20 | 0.75 |
| ▸ | MAP3K6 | O95382 | 1/20 | 0.75 |
| ▸ | AKT1 | P31749 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22473975 | 0.91 | MAP3K5 (0.62) | MAP3K5MAP3K6AKT1 | |
| SCHEMBL22473977 | 0.90 | MAP3K5 (0.61) | MAP3K5MAP3K6AKT1 | |
| SCHEMBL22473946 | 0.86 | MAP3K5 (0.74) | MAP3K5MAP3K6 | |
| Selonsertib SCHEMBL14672984 | 0.85 | MAP3K5 (1.00) | MAP3K5MAP3K6 | |
| Selonsertib SCHEMBL29977277 | 0.85 | MAP3K5 (1.00) | MAP3K5MAP3K6 | |
| Selonsertib SCHEMBL17873132 | 0.85 | MAP3K5 (0.98) | MAP3K5MAP3K6 | |
| Selonsertib SCHEMBL17873174 | 0.84 | MAP3K5 (0.96) | MAP3K5MAP3K6 | |
| Selonsertib SCHEMBL17873147 | 0.83 | MAP3K5 (0.94) | MAP3K5MAP3K6 | |
| Selonsertib SCHEMBL17873177 | 0.83 | MAP3K5 (0.94) | MAP3K5MAP3K6 | |
| SCHEMBL29978005 | 0.82 | MAP3K5 (0.78) | MAP3K5MAP3K6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3572401-B1 | ASK1 INHIBITOR AND PREPARATION METHOD AND USE THEREOF | FUJIAN COSUNTER PHARMACEUTICAL CO LTD (CN) | 2021-09-29 | — | — | EP | disclosed |
| US-10787435-B2 | ASK1 inhibitor and preparation method and use thereof | Fuijan Cosunter Pharmaceutical Co. Ltd. (CN) | 2020-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10787435-B2 | ASK1 inhibitor and preparation method and use thereof | MARK1, MAP3K1, MAP3K20 | MAP3K5 10/4885MAP3K6 6/4885AKT1 250/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.