SCHEMBL22474486

SCHEMBL22474486

CN1C[C@@H]2Cc3cccc(P(c4ccccc4)c4ccccc4)c3O[C@@H](Cc3cccc(P(c4ccccc4)c4ccccc4)c3O2)C1

nearest known ligand 0.40

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
DRD1 P21728 2/20 0.40
SLC6A2 P23975 2/20 0.30
SLC6A3 Q01959 2/20 0.30
SLC6A4 P31645 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22474500 1.00 DRD1 (0.40) DRD1SLC6A2SLC6A3SLC6A4
SCHEMBL22474474 0.84 DRD1 (0.42) DRD1
SCHEMBL20988606 0.82 DRD1 (0.40) DRD1
SCHEMBL20822406 0.82 DRD1 (0.40) DRD1
SCHEMBL22474460 0.82 DRD1 (0.40) DRD1
SCHEMBL21703407 0.82 DRD1 (0.40) DRD1
SCHEMBL22474508 0.82 DRD1 (0.40) DRD1
SCHEMBL22474493 0.82 DRD1 (0.40) DRD1
SCHEMBL22474515 0.81 DRD1 (0.39) DRD1
SCHEMBL22474484 0.81 DRD1 (0.39) DRD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2876108-B1 COMPOUNDS OF CHIRAL AROMATIC SPIROKETAL DIPHOSPHINE LIGANDS, PREPARATION METHODS AND USES THEREOF SHANGHAI INST ORGANIC CHEMISTRY CAS (CN) 2020-09-30 EP disclosed