Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 9/20 | 0.41 |
| ▸ | HASPIN | Q8TF76 | 8/20 | 0.35 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22474560 | 0.89 | DYRK1A (0.40) | DYRK1AHASPINDYRK2HTR2AHTR2C | |
| SCHEMBL20122904 | 0.76 | DYRK1A (0.42) | DYRK1AHASPINDYRK2ACHE | |
| SCHEMBL20122764 | 0.73 | DYRK1A (0.50) | DYRK1AHASPINDYRK2HTR2AHTR2C | |
| SCHEMBL20122710 | 0.72 | MEN1 (0.34) | DYRK1A | |
| SCHEMBL29756351 | 0.66 | DYRK1A (0.45) | DYRK1AHASPINDYRK2HTR2AHTR2C | |
| SCHEMBL20123023 | 0.66 | DYRK1A (0.45) | DYRK1AHASPINDYRK2HTR2AHTR2C | |
| SCHEMBL29756325 | 0.66 | DYRK1A (0.41) | DYRK1AHASPINDYRK2ACHE | |
| SCHEMBL20122935 | 0.66 | DYRK1A (0.41) | DYRK1AHASPINDYRK2AAK1 | |
| SCHEMBL20123032 | 0.66 | DYRK1A (0.41) | DYRK1AHASPINDYRK2ACHE | |
| SCHEMBL30664285 | 0.66 | DYRK1A (0.41) | DYRK1AHASPINDYRK2AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3535263-B1 | SUBSTITUTED PYRIDO[3,4-B]INDOLES FOR THE TREATMENT OF CARTILAGE DISORDERS | SANOFI SA (FR) | 2020-09-30 | — | — | EP | disclosed |