Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCK | P08631 | 7/20 | 0.61 |
| ▸ | BTK | Q06187 | 7/20 | 0.61 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | INSR | P06213 | 1/20 | 0.42 |
| ▸ | FLT4 | P35916 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 4/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.41 |
| ▸ | ITK | Q08881 | 1/20 | 0.41 |
| ▸ | GPR39 | O43194 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.39 |
| ▸ | CDK7 | P50613 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19229775 | 0.87 | HCK (0.63) | HCKBTKKDRLCKAURKB | |
| SCHEMBL22474750 | 0.84 | HCK (0.60) | HCKBTKKDRPRKCD | |
| SCHEMBL19205364 | 0.84 | HCK (0.60) | HCKBTKKDRLCKAURKB | |
| SCHEMBL19240435 | 0.82 | HCK (0.57) | HCKBTKKDRLCKAURKB | |
| SCHEMBL19229776 | 0.80 | BTK (0.75) | HCKBTKKDRLCKAURKB | |
| SCHEMBL19205354 | 0.76 | HCK (1.00) | HCKBTKKDRLCKAURKB | |
| SCHEMBL21980960 | 0.75 | BTK (0.72) | HCKBTKKDRLCKAURKB | |
| SCHEMBL19205442 | 0.74 | BTK (1.00) | HCKBTKITK | |
| SCHEMBL19205329 | 0.74 | BTK (1.00) | HCKBTKITK | |
| SCHEMBL19205330 | 0.74 | BTK (1.00) | HCKBTKITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3715346-A1 | THIAZOLYL-CONTAINING COMPOUNDS FOR TREATING PROLIFERATIVE DISEASES | Dana-Farber Cancer Institute (US) | 2020-09-30 | — | — | EP | disclosed |