Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 14/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 7/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | MMP2 | P08253 | 2/20 | 0.35 |
| ▸ | MMP9 | P14780 | 2/20 | 0.35 |
| ▸ | MMP8 | P22894 | 2/20 | 0.35 |
| ▸ | MMP13 | P45452 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24472782 | 0.81 | HDAC1 (0.37) | HDAC6HDAC8HDAC11HDAC3HDAC1 | |
| SCHEMBL22482920 | 0.80 | HDAC6 (0.56) | HDAC6HDAC8HDAC11HDAC3HDAC1 | |
| SCHEMBL22482900 | 0.72 | HDAC6 (0.70) | HDAC6HDAC8HDAC11HDAC3HDAC1 | |
| SCHEMBL22482997 | 0.72 | HDAC6 (0.53) | HDAC6HDAC8HDAC11HDAC3HDAC1 | |
| SCHEMBL24472779 | 0.72 | HDAC6 (0.53) | HDAC6HDAC8HDAC11HDAC3HDAC1 | |
| SCHEMBL20847659 | 0.65 | HDAC6 (0.67) | HDAC6HDAC8HDAC11HDAC3MEN1 | |
| SCHEMBL24473209 | 0.64 | HDAC6 (0.71) | HDAC6HDAC8HDAC11HDAC3HDAC1 | |
| SCHEMBL19712545 | 0.64 | HDAC1 (0.37) | HDAC6HDAC8HDAC11HDAC3HDAC1 | |
| SCHEMBL22482922 | 0.62 | HDAC1 (0.48) | HDAC6HDAC8HDAC11HDAC3HDAC1 | |
| SCHEMBL10042368 | 0.61 | HDAC3 (0.47) | HDAC6HDAC8HDAC11HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220169598-A1 | HALOGENATED PHENYLSULFONAMIDE HYDROXAMIC ACID COMPOUNDS, COMPOSITIONS AND USES THEREOF AS SELECTIVE HDAC6 INHIBITORS | 2681603 ONTARIO INC. (CA) | 2022-06-02 | — | — | US | disclosed |
| WO-2020194272-A1 | HALOGENATED PHENYLSULFONAMIDE HYDROXAMIC ACID COMPOUNDS, COMPOSITIONS AND USES THEREOF AS SELECTIVE HDAC6 INHIBITORS | 2681603 ONTARIO INC. (CA) | 2020-10-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220169598-A1 | HALOGENATED PHENYLSULFONAMIDE HYDROXAMIC ACID COMPOUNDS, COMPOSITIONS AND USES THEREOF AS SELECTIVE HDAC6 INHIBITORS | HDAC6, HDAC1, HDAC11 | HDAC6 1/4885HDAC8 11/4885HDAC11 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.