Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 17/20 | 0.70 |
| ▸ | HDAC1 | Q13547 | 10/20 | 0.70 |
| ▸ | HDAC3 | O15379 | 10/20 | 0.68 |
| ▸ | HDAC8 | Q9BY41 | 11/20 | 0.64 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.56 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.56 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22482990 | 0.82 | HDAC6 (0.65) | HDAC6HDAC1HDAC3HDAC8HDAC2 | |
| SCHEMBL22482984 | 0.81 | HDAC6 (1.00) | HDAC6HDAC1HDAC3HDAC8HSP90AA1 | |
| SCHEMBL15221191 | 0.75 | TP53 (0.50) | HDAC6HDAC3 | |
| SCHEMBL22482716 | 0.75 | HDAC6 (0.76) | HDAC6HDAC3HDAC8HDAC11 | |
| SCHEMBL13261470 | 0.75 | HDAC6 (0.64) | HDAC6HDAC1HDAC3HDAC8HDAC2 | |
| SCHEMBL22483022 | 0.74 | HDAC6 (1.00) | HDAC6HDAC1HDAC3HDAC8HDAC11 | |
| SCHEMBL3611117 | 0.74 | HDAC6 (0.58) | HDAC6HDAC1HDAC3HDAC8HDAC7 | |
| SCHEMBL6570639 | 0.73 | HDAC1 (0.74) | HDAC6HDAC1HDAC3HDAC8HSP90AA1 | |
| SCHEMBL29245128 | 0.72 | HSP90AA1 (1.00) | HDAC6HDAC1HDAC3HDAC8HSP90AA1 | |
| SCHEMBL22482763 | 0.71 | HDAC6 (0.81) | HDAC6HDAC1HDAC3HDAC8HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020194272-A1 | HALOGENATED PHENYLSULFONAMIDE HYDROXAMIC ACID COMPOUNDS, COMPOSITIONS AND USES THEREOF AS SELECTIVE HDAC6 INHIBITORS | 2681603 ONTARIO INC. (CA) | 2020-10-01 | — | — | WO | disclosed |