Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 14/20 | 0.47 |
| ▸ | RAF1 | P04049 | 9/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | ARAF | P10398 | 1/20 | 0.47 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.47 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22488036 | 0.84 | CYP2C19 (0.44) | BRAFRAF1CYP2C19KMT2ACRHBP | |
| SCHEMBL22488040 | 0.83 | CYP2C19 (0.40) | BRAFRAF1PDGFRBARAFDDR1 | |
| SCHEMBL22488583 | 0.83 | CYP2C19 (0.40) | BRAFRAF1PDGFRBARAFDDR1 | |
| SCHEMBL22488000 | 0.82 | BRAF (0.46) | BRAFCYP2C19KMT2ACRHBPCRHR2 | |
| SCHEMBL22488304 | 0.82 | ATR (0.47) | BRAFRAF1CYP2C19KMT2ACRHBP | |
| SCHEMBL22487967 | 0.81 | CYP2C19 (0.44) | BRAFRAF1CYP2C19KMT2ACRHBP | |
| SCHEMBL22488429 | 0.81 | CYP2C19 (0.43) | BRAFRAF1CYP2C19KMT2ACRHBP | |
| SCHEMBL22488325 | 0.80 | CYP2C19 (0.42) | CYP2C19KMT2ACRHBPCRHR2ALDH1A1 | |
| SCHEMBL24885817 | 0.78 | BRAF (0.58) | BRAFRAF1PDGFRBARAFDDR1 | |
| SCHEMBL30078044 | 0.78 | BRAF (0.58) | BRAFRAF1PDGFRBARAFDDR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020198058-A1 | INHIBITORS OF RAF KINASES | KINNATE BIOPHARMA INC. (US) | 2020-10-01 | — | — | WO | disclosed |