Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 18/20 | 0.81 |
| ▸ | RAF1 | P04049 | 11/20 | 0.66 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.66 |
| ▸ | ARAF | P10398 | 1/20 | 0.66 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.66 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30291570 | 1.00 | BRAF (0.81) | BRAFRAF1PDGFRBARAFDDR1 | |
| SCHEMBL22488301 | 0.91 | BRAF (0.76) | BRAFRAF1PDGFRBARAFDDR1 | |
| SCHEMBL22488296 | 0.90 | BRAF (0.79) | BRAFRAF1PDGFRBARAFDDR1 | |
| SCHEMBL22488488 | 0.89 | BRAF (0.82) | BRAFRAF1PDGFRBARAFDDR1 | |
| SCHEMBL22488293 | 0.89 | BRAF (1.00) | BRAFRAF1PDGFRBARAFDDR1 | |
| SCHEMBL22488292 | 0.89 | BRAF (1.00) | BRAFRAF1PDGFRBARAFDDR1 | |
| SCHEMBL22488512 | 0.88 | BRAF (0.82) | BRAFRAF1PDGFRBARAFDDR1 | |
| SCHEMBL30291706 | 0.88 | BRAF (0.82) | BRAFRAF1PDGFRBARAFDDR1 | |
| SCHEMBL22488551 | 0.88 | BRAF (0.92) | BRAFRAF1PDGFRBARAFDDR1 | |
| SCHEMBL22488303 | 0.88 | BRAF (0.76) | BRAFRAF1PDGFRBARAFDDR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020198058-A1 | INHIBITORS OF RAF KINASES | KINNATE BIOPHARMA INC. (US) | 2020-10-01 | — | — | WO | disclosed |