Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 19/20 | 0.71 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.37 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | BLK | P51451 | 1/20 | 0.37 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.37 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.37 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL620157 | 0.84 | CHEK1 (1.00) | CHEK1CHEK2KCNH2NUAK1RPS6KB1 | |
| SCHEMBL620075 | 0.79 | CHEK1 (0.69) | CHEK1CHEK2KCNH2 | |
| SCHEMBL20322032 | 0.78 | CHEK1 (0.47) | CHEK1CHEK2 | |
| SCHEMBL619766 | 0.76 | CHEK1 (1.00) | CHEK1CHEK2KCNH2NUAK1RPS6KB1 | |
| SCHEMBL619787 | 0.75 | CHEK1 (0.93) | CHEK1CHEK2KCNH2NUAK1RPS6KB1 | |
| SCHEMBL1119557 | 0.74 | DPP7 (0.50) | CHEK1 | |
| SCHEMBL24056640 | 0.72 | CHEK1 (0.49) | CHEK1 | |
| Hydrochloric Acid SCHEMBL1119507 | 0.72 | DPP7 (0.49) | CHEK1 | |
| Hydrochloric Acid SCHEMBL1960447 | 0.72 | DPP7 (0.49) | CHEK1 | |
| SCHEMBL13390998 | 0.72 | CHEK1 (0.41) | CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020198526-A2 | SMALL MOLECULE MODULATORS OF PANK | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2020-10-01 | — | — | WO | disclosed |