Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.33 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.33 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.31 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5290699 | 0.98 | SLC22A2 (0.34) | KMT2APCSK9NPSR1L3MBTL1SLC22A2 | |
| SCHEMBL5287084 | 0.76 | KMT2A (0.35) | KMT2AMAPTHTTSMN1; SMN2 | |
| SCHEMBL5333131 | 0.75 | BCHE (0.33) | SLC22A2SLC22A1SLC22A3SLC6A4MAPT | |
| SCHEMBL5282605 | 0.75 | HTT (0.40) | KMT2ASLC22A2SLC22A1SLC22A3SLC6A4 | |
| SCHEMBL1834751 | 0.75 | MAPT (0.39) | KMT2ANPSR1L3MBTL1MAPTHTT | |
| SCHEMBL1830961 | 0.75 | NPSR1 (0.47) | KMT2APCSK9NPSR1L3MBTL1SLC22A2 | |
| SCHEMBL5292666 | 0.74 | KMT2A (0.42) | KMT2ANPSR1MAPTNPC1RAB9A | |
| SCHEMBL5304618 | 0.72 | EEF2K (0.49) | KMT2AMAPTHTT | |
| SCHEMBL5298292 | 0.72 | EEF2K (0.49) | KMT2AMAPTHTT | |
| SCHEMBL5287206 | 0.72 | EEF2K (0.49) | KMT2AMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3717495-A1 | PHOSPHORESCENT PLATINUM (II) ANHC COMPLEXES | Technische Universität Dresden (DE) | 2020-10-07 | — | — | EP | disclosed |