Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.52 |
| ▸ | ACE | P12821 | 3/20 | 0.52 |
| ▸ | FNTA | P49354 | 3/20 | 0.40 |
| ▸ | FNTB | P49356 | 2/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 7/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 7/20 | 0.39 |
| ▸ | PPARG | P37231 | 3/20 | 0.38 |
| ▸ | PPARA | Q07869 | 2/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.37 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.37 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.37 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.37 |
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8249070 | 0.88 | ACE (0.58) | ACE2ACEFNTAFNTBCYP11B1 | |
| SCHEMBL5869812 | 0.88 | ACE (0.58) | ACE2ACEFNTAFNTBCYP11B1 | |
| SCHEMBL1659753 | 0.86 | ACE2 (0.70) | ACE2ACEFNTACYP11B1CYP11B2 | |
| SCHEMBL8249097 | 0.86 | ACE2 (0.70) | ACE2ACEFNTACYP11B1CYP11B2 | |
| SCHEMBL22491305 | 0.83 | ACE2 (0.53) | ACE2ACEFNTAFNTBCYP11B1 | |
| SCHEMBL22491297 | 0.83 | ACE2 (0.46) | ACE2ACEFNTAFNTBCYP11B1 | |
| SCHEMBL22491299 | 0.82 | ACE2 (0.45) | ACE2ACEFNTAFNTBCYP11B1 | |
| SCHEMBL6834243 | 0.81 | ACE2 (0.57) | ACE2ACEFNTAFNTBCYP11B1 | |
| SCHEMBL8249140 | 0.78 | ACE2 (0.70) | ACE2ACEFNTAFNTBCYP11B1 | |
| SCHEMBL1660431 | 0.78 | ACE2 (0.70) | ACE2ACEFNTAFNTBCYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3717077-A1 | METHODS FOR MODULATING PIGMENTATION BY ANGIOTENSIN-CONVERTING ENZYME 2 MODULATION | Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (DE) | 2020-10-07 | — | — | EP | disclosed |