Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Imidapril. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE known ✓ | P12821 | 13/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 0.66 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | USP2 | O75604 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Imidapril SCHEMBL12894585 | 1.00 | ACE (1.00) | ACELMNAABCB11MEN1KMT2A | |
| Imidapril SCHEMBL34098 | 1.00 | ACE (1.00) | ACELMNAABCB11MEN1KMT2A | |
| Imidapril SCHEMBL3193644 | 1.00 | ACE (1.00) | ACELMNAABCB11MEN1KMT2A | |
| Imidapril SCHEMBL11014327 | 1.00 | ACE (1.00) | ACELMNAABCB11MEN1KMT2A | |
| Imidapril SCHEMBL34099 | 1.00 | ACE (1.00) | ACELMNAABCB11MEN1KMT2A | |
| Imidapril SCHEMBL683273 | 1.00 | ACE (1.00) | ACELMNAABCB11MEN1KMT2A | |
| Imidapril SCHEMBL7354516 | 1.00 | ACE (1.00) | ACELMNAABCB11MEN1KMT2A | |
| Imidapril SCHEMBL6516062 | 1.00 | ACE (1.00) | ACELMNAABCB11MEN1KMT2A | |
| Imidapril SCHEMBL7294155 | 0.99 | ACE (0.98) | ACELMNAABCB11MEN1KMT2A | |
| Imidapril SCHEMBL136722 | 0.99 | ACE (0.98) | ACELMNAABCB11MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4744654-A1 | SIGMA-1 RECEPTOR AGONIST SYSTOLIC BLOOD PRESSURE THERAPY | Anavex Life Sciences Corp. (US) | 2026-05-20 | — | — | EP | disclosed |
| US-12280034-B2 | Sigma-1 receptor agonist systolic blood pressure therapy | ANAVEX LIFE SCIENCES CORP. (US) | 2025-04-22 | — | — | US | disclosed |
| CN-118067870-A | Rapid screening method for nebivolol and imidapril | 苏州市药品检验检测研究中心（苏州市药品不良反应监测中心） | 2024-05-24 | — | — | CN | disclosed |
| US-11622955-B2 | Sigma-1 receptor agonist systolic blood pressure therapy | ANAVEX LIFE SCIENCES CORP. (US) | 2023-04-11 | — | — | US | disclosed |
| US-20230071766-A1 | SIGMA-1 RECEPTOR AGONIST SYSTOLIC BLOOD PRESSURE THERAPY | ANAVEX LIFE SCIENCES CORP. (US) | 2023-03-09 | — | — | US | disclosed |
| US-20210186920-A1 | SIGMA-1 RECEPTOR AGONIST SYSTOLIC BLOOD PRESSURE THERAPY | ANAVEX LIFE SCIENCES CORP. (US) | 2021-06-24 | — | — | US | disclosed |
| US-20210145964-A1 | STROMA-TARGETING TREATMENT FOR PATIENTS WITH ELEVATED ADAM12 LEVELS | ACADEMISCH MEDISCH CENTRUM (NL) | 2021-05-20 | — | — | US | disclosed |
| CN-105713068-B | Method for preparing imidapril key intermediate and derivative thereof | 湖南九典制药股份有限公司 | 2021-04-20 | — | — | CN | disclosed |
| EP-3716968-A1 | SIGMA-1 RECEPTOR AGONIST SYSTOLIC BLOOD PRESSURE THERAPY | Anavex Life Sciences Corp. (US) | 2020-10-07 | — | — | EP | disclosed |
| CN-111712241-A | Sigma-1 receptor agonist systolic blood pressure therapy | 阿纳韦克斯生命科学公司 | 2020-09-25 | — | — | CN | disclosed |
| CN-104119424-B | The preparation method of (4S) -3- [(2S) -2 [(1S) -1- ethoxycarbonyl-3-phenylpropyl] aminopropionyl] -1- methyl -2- oxoimidazolinium -4- carboxylic acid | 上海天慈生物谷生物工程有限公司 | 2018-12-18 | — | — | CN | disclosed |
| CN-104119424-B | The preparation method of (4S) -3- [(2S) -2 [(1S) -1- ethoxycarbonyl-3-phenylpropyl] aminopropionyl] -1- methyl -2- oxoimidazolinium -4- carboxylic acid | 上海天慈生物谷生物工程有限公司 | 2018-12-18 | — | — | CN | disclosed |