SCHEMBL22492858

SCHEMBL22492858

CCS(=O)(=O)Nc1cc(-c2cn(C)c(=O)c3[nH]ccc23)nc2c1ncn2Cc1ccc(F)cc1F

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ BRD4 O60885 20/20 1.00
▸ BRD2 P25440 1/20 0.51
▸ ADORA2B P29275 1/20 0.51
▸ TSPO P30536 1/20 0.51
▸ EP300 Q09472 1/20 0.51
▸ BRD3 Q15059 1/20 0.51
▸ BRDT Q58F21 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22492902 0.89 BRD4 (1.00) BRD4BRD2ADORA2BTSPOEP300
SCHEMBL22516419 0.88 BRD4 (0.79) BRD4BRD2ADORA2BTSPOEP300
SCHEMBL22492905 0.87 BRD4 (0.82) BRD4BRD2ADORA2BTSPOEP300
SCHEMBL28465833 0.87 BRD4 (0.77) BRD4
SCHEMBL22492900 0.87 BRD4 (1.00) BRD4BRD2ADORA2BTSPOEP300
SCHEMBL22516421 0.85 BRD4 (0.90) BRD4BRD2ADORA2BTSPOEP300
SCHEMBL22492922 0.85 BRD4 (0.77) BRD4
SCHEMBL29977106 0.85 BRD4 (0.77) BRD4
SCHEMBL22492854 0.84 BRD4 (1.00) BRD4
SCHEMBL28465834 0.84 BRD4 (0.81) BRD4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11466034-B2 Compound functioning as bromodomain protein inhibitor, and composition BETTA PHARMACEUTICALS CO., LTD. (CN) 2022-10-11 — — US claimed
US-20200385408-A1 COMPOUND FUNCTIONING AS BROMODOMAIN PROTEIN INHIBITOR, AND COMPOSITION BETTA PHARMACEUTICALS CO., LTD. (CN) 2020-12-10 — — US claimed
EP-3719017-A2 COMPOUND FUNCTIONING AS BROMODOMAIN PROTEIN INHIBITOR, AND COMPOSITION Betta Pharmaceuticals Co., Ltd. (CN) 2020-10-07 — — EP claimed
US-11845762-B2 Compound functioning as bromodomain protein inhibitor, and composition BETTA PHARMACEUTICALS CO., LTD. (CN) 2023-12-19 — — US disclosed
US-20230022091-A1 COMPOUND FUNCTIONING AS BROMODOMAIN PROTEIN INHIBITOR, AND COMPOSITION BETTA PHARMACEUTICALS CO., LTD. (CN) 2023-01-26 — — US disclosed
US-20230022091-A1 COMPOUND FUNCTIONING AS BROMODOMAIN PROTEIN INHIBITOR, AND COMPOSITION BETTA PHARMACEUTICALS CO., LTD. (CN) 2023-01-26 — — US disclosed
US-11466034-B2 Compound functioning as bromodomain protein inhibitor, and composition BETTA PHARMACEUTICALS CO., LTD. (CN) 2022-10-11 — — US disclosed
US-11466034-B2 Compound functioning as bromodomain protein inhibitor, and composition BETTA PHARMACEUTICALS CO., LTD. (CN) 2022-10-11 — — US disclosed
US-20200385408-A1 COMPOUND FUNCTIONING AS BROMODOMAIN PROTEIN INHIBITOR, AND COMPOSITION BETTA PHARMACEUTICALS CO., LTD. (CN) 2020-12-10 — — US disclosed
US-20200385408-A1 COMPOUND FUNCTIONING AS BROMODOMAIN PROTEIN INHIBITOR, AND COMPOSITION BETTA PHARMACEUTICALS CO., LTD. (CN) 2020-12-10 — — US disclosed
EP-3719017-A2 COMPOUND FUNCTIONING AS BROMODOMAIN PROTEIN INHIBITOR, AND COMPOSITION Betta Pharmaceuticals Co., Ltd. (CN) 2020-10-07 — — EP disclosed
EP-3719017-A2 COMPOUND FUNCTIONING AS BROMODOMAIN PROTEIN INHIBITOR, AND COMPOSITION Betta Pharmaceuticals Co., Ltd. (CN) 2020-10-07 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11466034-B2 Compound functioning as bromodomain protein inhibitor, and composition BRD4, BRD1, BRD2 BRD4 1/4885BRD2 3/4885ADORA2B 4634/4885
US-20230022091-A1 COMPOUND FUNCTIONING AS BROMODOMAIN PROTEIN INHIBITOR, AND COMPOSITION BRD4, BRD1, BRD2 BRD4 1/4885BRD2 3/4885ADORA2B 4634/4885
US-11845762-B2 Compound functioning as bromodomain protein inhibitor, and composition BRD4, BRD1, BRD2 BRD4 1/4885BRD2 3/4885ADORA2B 4634/4885
US-20200385408-A1 COMPOUND FUNCTIONING AS BROMODOMAIN PROTEIN INHIBITOR, AND COMPOSITION BRD4, BRD1, BRD2 BRD4 1/4885BRD2 3/4885ADORA2B 4634/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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