SCHEMBL22492908

SCHEMBL22492908

CCn1cc(-c2cnc3nc(C)n(Cc4ccc(OC)cc4)c3c2)c2cc[nH]c2c1=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ BRD4 O60885 19/20 1.00
▸ CECR2 Q9BXF3 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22492885 0.92 BRD4 (0.85) BRD4
SCHEMBL22492857 0.92 BRD4 (1.00) BRD4
SCHEMBL22492907 0.91 BRD4 (1.00) BRD4
SCHEMBL22516668 0.89 BRD4 (1.00) BRD4CECR2
SCHEMBL22492853 0.89 BRD4 (0.80) BRD4
SCHEMBL29976771 0.88 BRD4 (1.00) BRD4
SCHEMBL22492906 0.88 BRD4 (1.00) BRD4
SCHEMBL22492910 0.82 BRD4 (1.00) BRD4
SCHEMBL29976622 0.82 BRD4 (1.00) BRD4
SCHEMBL22492851 0.81 BRD4 (1.00) BRD4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111712496-B Compounds and compositions as bromodomain protein inhibitors 贝达药业股份有限公司 2023-05-02 — — CN claimed
US-11466034-B2 Compound functioning as bromodomain protein inhibitor, and composition BETTA PHARMACEUTICALS CO., LTD. (CN) 2022-10-11 — — US claimed
US-20200385408-A1 COMPOUND FUNCTIONING AS BROMODOMAIN PROTEIN INHIBITOR, AND COMPOSITION BETTA PHARMACEUTICALS CO., LTD. (CN) 2020-12-10 — — US claimed
EP-3719017-A2 COMPOUND FUNCTIONING AS BROMODOMAIN PROTEIN INHIBITOR, AND COMPOSITION Betta Pharmaceuticals Co., Ltd. (CN) 2020-10-07 — — EP claimed
US-11845762-B2 Compound functioning as bromodomain protein inhibitor, and composition BETTA PHARMACEUTICALS CO., LTD. (CN) 2023-12-19 — — US disclosed
CN-111712496-B Compounds and compositions as bromodomain protein inhibitors 贝达药业股份有限公司 2023-05-02 — — CN disclosed
US-20230022091-A1 COMPOUND FUNCTIONING AS BROMODOMAIN PROTEIN INHIBITOR, AND COMPOSITION BETTA PHARMACEUTICALS CO., LTD. (CN) 2023-01-26 — — US disclosed
US-20230022091-A1 COMPOUND FUNCTIONING AS BROMODOMAIN PROTEIN INHIBITOR, AND COMPOSITION BETTA PHARMACEUTICALS CO., LTD. (CN) 2023-01-26 — — US disclosed
US-11466034-B2 Compound functioning as bromodomain protein inhibitor, and composition BETTA PHARMACEUTICALS CO., LTD. (CN) 2022-10-11 — — US disclosed
US-11466034-B2 Compound functioning as bromodomain protein inhibitor, and composition BETTA PHARMACEUTICALS CO., LTD. (CN) 2022-10-11 — — US disclosed
US-20200385408-A1 COMPOUND FUNCTIONING AS BROMODOMAIN PROTEIN INHIBITOR, AND COMPOSITION BETTA PHARMACEUTICALS CO., LTD. (CN) 2020-12-10 — — US disclosed
US-20200385408-A1 COMPOUND FUNCTIONING AS BROMODOMAIN PROTEIN INHIBITOR, AND COMPOSITION BETTA PHARMACEUTICALS CO., LTD. (CN) 2020-12-10 — — US disclosed
EP-3719017-A2 COMPOUND FUNCTIONING AS BROMODOMAIN PROTEIN INHIBITOR, AND COMPOSITION Betta Pharmaceuticals Co., Ltd. (CN) 2020-10-07 — — EP disclosed
EP-3719017-A2 COMPOUND FUNCTIONING AS BROMODOMAIN PROTEIN INHIBITOR, AND COMPOSITION Betta Pharmaceuticals Co., Ltd. (CN) 2020-10-07 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11466034-B2 Compound functioning as bromodomain protein inhibitor, and composition BRD4, BRD1, BRD2 BRD4 1/4885CECR2 1299/4885
US-20230022091-A1 COMPOUND FUNCTIONING AS BROMODOMAIN PROTEIN INHIBITOR, AND COMPOSITION BRD4, BRD1, BRD2 BRD4 1/4885CECR2 1299/4885
US-11845762-B2 Compound functioning as bromodomain protein inhibitor, and composition BRD4, BRD1, BRD2 BRD4 1/4885CECR2 1299/4885
US-20200385408-A1 COMPOUND FUNCTIONING AS BROMODOMAIN PROTEIN INHIBITOR, AND COMPOSITION BRD4, BRD1, BRD2 BRD4 1/4885CECR2 1299/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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