Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT2 | P31751 | 16/20 | 0.66 |
| ▸ | AKT1 | P31749 | 13/20 | 0.59 |
| ▸ | ROCK2 | O75116 | 7/20 | 0.58 |
| ▸ | AKT3 | Q9Y243 | 7/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | GSK3B | P49841 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22493045 | 0.91 | AKT2 (0.65) | AKT2AKT1ROCK2AKT3KCNH2 | |
| SCHEMBL22493043 | 0.91 | AKT2 (0.65) | AKT2AKT1ROCK2AKT3KCNH2 | |
| SCHEMBL22493038 | 0.85 | AKT2 (0.68) | AKT2AKT1ROCK2AKT3KCNH2 | |
| SCHEMBL22493041 | 0.84 | AKT2 (0.65) | AKT2AKT1ROCK2AKT3KCNH2 | |
| SCHEMBL2780797 | 0.83 | AKT2 (0.67) | AKT2AKT1ROCK2AKT3KCNH2 | |
| SCHEMBL22493037 | 0.83 | AKT2 (0.64) | AKT2AKT1ROCK2AKT3KCNH2 | |
| SCHEMBL22493044 | 0.81 | AKT2 (0.67) | AKT2AKT1ROCK2AKT3KCNH2 | |
| SCHEMBL22493035 | 0.81 | AKT2 (0.66) | AKT2AKT1ROCK2AKT3KCNH2 | |
| SCHEMBL1002358 | 0.80 | AKT2 (1.00) | AKT2AKT1ROCK2AKT3KCNH2 | |
| SCHEMBL22493036 | 0.77 | AKT2 (0.68) | AKT2AKT1ROCK2AKT3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3421471-B1 | PURINE AND DEAZAPURINE DERIVATIVES AS PHARMACEUTICAL COMPOUNDS | ASTEX THERAPEUTICS LTD (GB) | 2021-05-26 | — | — | EP | disclosed |
| EP-3719018-A1 | PURINE AND DEAZAPURINE DERIVATIVES AS PHARMACEUTICAL COMPOUNDS | Astex Therapeutics Ltd (GB) | 2020-10-07 | — | — | EP | disclosed |