SCHEMBL22493055

SCHEMBL22493055

O=C(OBr)c1ncc2cc(Oc3ccccc3)ccc2c1O

nearest known ligand 0.65

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
EGLN1 Q9GZT9 15/20 0.65
EGLN2 Q96KS0 19/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28627889 0.89 EGLN1 (0.66) EGLN1EGLN2
SCHEMBL22493051 0.88 EGLN1 (0.65) EGLN1EGLN2
SCHEMBL15268823 0.88 EGLN1 (0.68) EGLN1EGLN2
SCHEMBL31238805 0.88 EGLN1 (0.68) EGLN1EGLN2
SCHEMBL29898493 0.88 EGLN1 (0.68) EGLN1EGLN2
SCHEMBL21361727 0.87 EGLN1 (0.70) EGLN1EGLN2
SCHEMBL29726498 0.87 EGLN1 (0.70) EGLN1EGLN2
SCHEMBL30394217 0.85 EGLN1 (0.67) EGLN1EGLN2
SCHEMBL523263 0.84 EGLN1 (0.64) EGLN1EGLN2
SCHEMBL28936037 0.83 EGLN1 (0.60) EGLN1EGLN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3717456-A1 PROCESS FOR THE PREPARATION OF ROXADUSTAT AND ITS INTERMEDIATES Dr. Reddy's Laboratories Limited (IN) 2020-10-07 EP disclosed