Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 2/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.56 |
| ▸ | MET | P08581 | 16/20 | 0.54 |
| ▸ | AXL | P30530 | 7/20 | 0.54 |
| ▸ | KDR | P35968 | 4/20 | 0.54 |
| ▸ | RET | P07949 | 3/20 | 0.54 |
| ▸ | KIT | P10721 | 3/20 | 0.54 |
| ▸ | FLT3 | P36888 | 3/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.54 |
| ▸ | MERTK | Q12866 | 3/20 | 0.49 |
| ▸ | AURKA | O14965 | 2/20 | 0.49 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.49 |
| ▸ | ABL1 | P00519 | 2/20 | 0.49 |
| ▸ | EGFR | P00533 | 2/20 | 0.49 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.49 |
| ▸ | LCK | P06239 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28692805 | 0.92 | HDAC2 (0.56) | HDAC2HDAC8HDAC6HDAC10HDAC11 | |
| SCHEMBL30786374 | 0.92 | HDAC2 (0.56) | HDAC2HDAC8HDAC6HDAC10HDAC11 | |
| SCHEMBL29182979 | 0.92 | HDAC2 (0.56) | HDAC2HDAC8HDAC6HDAC10HDAC11 | |
| SCHEMBL28686931 | 0.90 | HDAC2 (0.57) | HDAC2HDAC8HDAC6HDAC10HDAC11 | |
| SCHEMBL15917325 | 0.89 | HDAC2 (0.70) | HDAC2HDAC8HDAC6HDAC10HDAC11 | |
| SCHEMBL15918114 | 0.89 | HDAC2 (0.70) | HDAC2HDAC8HDAC6HDAC10HDAC11 | |
| SCHEMBL15917470 | 0.89 | HDAC2 (0.70) | HDAC2HDAC8HDAC6HDAC10HDAC11 | |
| SCHEMBL15917808 | 0.89 | HDAC2 (0.70) | HDAC2HDAC8HDAC6HDAC10HDAC11 | |
| SCHEMBL15917659 | 0.89 | HDAC2 (0.69) | HDAC2HDAC8HDAC6HDAC10HDAC11 | |
| SCHEMBL15918162 | 0.89 | HDAC2 (0.69) | HDAC2HDAC8HDAC6HDAC10HDAC11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113924288-B | Quinolinyl-containing compound, pharmaceutical composition and application thereof | 北京普祺医药科技股份有限公司 | 2024-04-05 | — | — | CN | disclosed |
| CN-113924288-A | Quinolyl-containing compound, pharmaceutical composition and application thereof | 北京普祺医药科技有限公司 | 2022-01-11 | — | — | CN | disclosed |
| WO-2020200160-A1 | QUINOLYL-CONTAINING COMPOUND AND PHARMACEUTICAL COMPOSITION, AND USE THEREOF | 北京国鸿生物医药科技有限公司 | 2020-10-08 | — | — | WO | disclosed |