Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.62 |
| ▸ | ACACB | O00763 | 3/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.46 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.46 |
| ▸ | HTR3B | O95264 | 1/20 | 0.46 |
| ▸ | HTR1D | P28221 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HTR3A | P46098 | 1/20 | 0.46 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.46 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22499789 | 1.00 | NOTUM (0.62) | NOTUMACACBPOLBLMNAMAPK1 | |
| SCHEMBL27831958 | 0.87 | POLB (0.60) | NOTUMACACBPOLBLMNAMAPK1 | |
| SCHEMBL21624697 | 0.85 | NOTUM (0.59) | NOTUMLMNAKDM4E | |
| SCHEMBL21624699 | 0.85 | NOTUM (0.59) | NOTUMLMNAKDM4E | |
| SCHEMBL23387255 | 0.82 | ACACB (0.47) | NOTUMACACBLMNAALDH1A1KDM4E | |
| SCHEMBL23387252 | 0.82 | ACACB (0.47) | NOTUMACACBLMNAALDH1A1KDM4E | |
| SCHEMBL12210057 | 0.81 | NOTUM (0.63) | NOTUMACACBPOLBLMNATSHR | |
| SCHEMBL29117230 | 0.80 | NOTUM (0.55) | NOTUMACACBPOLBCYP2C9CYP2C19 | |
| SCHEMBL29117227 | 0.80 | NOTUM (0.55) | NOTUMACACBPOLBCYP2C9CYP2C19 | |
| SCHEMBL1410437 | 0.80 | NOTUM (0.62) | NOTUMACACBPOLBLMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020203610-A1 | USE OF T-TYPE CALCIUM CHANNEL BLOCKER FOR TREATING RHEUMATOID ARTHRITIS | 日本ケミファ株式会社 | 2020-10-08 | — | — | WO | disclosed |
| WO-2020203609-A1 | USE OF T-TYPE CALCIUM CHANNEL BLOCKER FOR TREATING PRURITUS | 日本ケミファ株式会社 | 2020-10-08 | — | — | WO | disclosed |