Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 19/20 | 0.76 |
| ▸ | GIPR | P48546 | 7/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2255043 | 0.89 | GCGR (0.73) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2253924 | 0.87 | GCGR (1.00) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2667889 | 0.86 | GCGR (0.76) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL13003258 | 0.86 | GCGR (0.87) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2250990 | 0.85 | GCGR (0.75) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2667307 | 0.85 | GCGR (0.85) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2667524 | 0.85 | GCGR (0.78) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2254559 | 0.85 | GCGR (0.78) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2251873 | 0.85 | GCGR (0.77) | GCGRGIPRCYP3A4CYP2C8CYP2C9 | |
| SCHEMBL2250235 | 0.84 | GCGR (0.73) | GCGRGIPRCYP3A4CYP2C8CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7989475-B2 | Substituted pyrazoles, compositions containing such compounds and methods of use | MERCK SHARP & DOHME CORP. (US) | 2011-08-02 | — | — | US | disclosed |