Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 10/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.38 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.38 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 12/20 | 0.38 |
| ▸ | EGFR | P00533 | 6/20 | 0.38 |
| ▸ | ABL1 | P00519 | 5/20 | 0.38 |
| ▸ | ABL2 | P42684 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 3/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.37 |
| ▸ | PRKDC | P78527 | 3/20 | 0.37 |
| ▸ | PI4KB | Q9UBF8 | 3/20 | 0.37 |
| ▸ | HCK | P08631 | 2/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.37 |
| ▸ | MTOR | P42345 | 2/20 | 0.37 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29641506 | 1.00 | PIK3CD (0.39) | PIK3CDPIK3CGPIK3R1CSNK1ESRC | |
| SCHEMBL30679714 | 0.87 | PIK3CD (0.41) | PIK3CDPIK3CGPIK3R1CSNK1ESRC | |
| SCHEMBL22504993 | 0.87 | PIK3CD (0.41) | PIK3CDPIK3CGPIK3R1CSNK1ESRC | |
| SCHEMBL24494704 | 0.87 | PIK3CD (0.41) | PIK3CDPIK3CGPIK3R1CSNK1ESRC | |
| SCHEMBL22505045 | 0.81 | NR1H2 (0.41) | — | |
| SCHEMBL29641539 | 0.81 | NR1H2 (0.41) | — | |
| SCHEMBL22504952 | 0.81 | PIK3CD (0.41) | PIK3CDPIK3CGPIK3R1CSNK1ESRC | |
| SCHEMBL24494691 | 0.81 | PIK3CD (0.41) | PIK3CDPIK3CGPIK3R1CSNK1ESRC | |
| Hydrochloric Acid SCHEMBL22498182 | 0.80 | PIK3CD (0.40) | PIK3CDPIK3CGPIK3R1CSNK1ESRC | |
| Hydrochloric Acid SCHEMBL30679720 | 0.80 | PIK3CD (0.40) | PIK3CDPIK3CGPIK3R1CSNK1ESRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3947384-B1 | ISOCHROMENE DERIVATIVES AS PHOSPHOINOSITIDE 3-KINASES INHIBITORS | CHIESI FARM SPA (IT) | 2023-11-01 | — | — | EP | disclosed |
| US-20220175784-A1 | ISOCHROMENE DERIVATIVES AS PHOSPHOINOSITIDE 3-KINASES INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2022-06-09 | — | — | US | disclosed |
| WO-2020200918-A1 | ISOCHROMENE DERIVATIVES AS PHOSPHOINOSITIDE 3-KINASES INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2020-10-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220175784-A1 | ISOCHROMENE DERIVATIVES AS PHOSPHOINOSITIDE 3-KINASES INHIBITORS | PIKFYVE, PDPK1, PIK3R5 | PIK3CD 5/4885PIK3CG 13/4885PIK3R1 19/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.