Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 15/20 | 0.87 |
| ▸ | WDR77 | Q9BQA1 | 5/20 | 0.87 |
| ▸ | METTL3 | Q86U44 | 8/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22509662 | 0.93 | PRMT5 (0.87) | PRMT5WDR77METTL3 | |
| Onametostat SCHEMBL22468844 | 0.93 | PRMT5 (1.00) | PRMT5WDR77METTL3 | |
| Onametostat SCHEMBL29352669 | 0.93 | PRMT5 (1.00) | PRMT5WDR77METTL3 | |
| Onametostat SCHEMBL29349847 | 0.93 | PRMT5 (1.00) | PRMT5WDR77METTL3 | |
| Onametostat SCHEMBL25318935 | 0.93 | PRMT5 (1.00) | PRMT5WDR77METTL3 | |
| Onametostat SCHEMBL25427100 | 0.93 | PRMT5 (1.00) | PRMT5WDR77METTL3 | |
| Onametostat SCHEMBL22749068 | 0.93 | PRMT5 (1.00) | PRMT5WDR77METTL3 | |
| Onametostat SCHEMBL22749057 | 0.93 | PRMT5 (1.00) | PRMT5WDR77METTL3 | |
| Onametostat SCHEMBL29394859 | 0.93 | PRMT5 (1.00) | PRMT5WDR77METTL3 | |
| Onametostat SCHEMBL29485640 | 0.93 | PRMT5 (1.00) | PRMT5WDR77METTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020205867-A1 | COMPOUNDS TARGETING PRMT5 | ALIGOS THERAPEUTICS, INC. (US) | 2020-10-08 | — | — | WO | disclosed |