Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 20/20 | 0.86 |
| ▸ | FGFR2 | P21802 | 17/20 | 0.86 |
| ▸ | FGFR4 | P22455 | 17/20 | 0.86 |
| ▸ | FGFR3 | P22607 | 17/20 | 0.86 |
| ▸ | KDR | P35968 | 13/20 | 0.86 |
| ▸ | FLT1 | P17948 | 12/20 | 0.86 |
| ▸ | FLT4 | P35916 | 12/20 | 0.86 |
| ▸ | SRC | P12931 | 3/20 | 0.68 |
| ▸ | GLA | P06280 | 1/20 | 0.68 |
| ▸ | CSK | P41240 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.68 |
| ▸ | ATM | Q13315 | 1/20 | 0.68 |
| ▸ | EGFR | P00533 | 3/20 | 0.62 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.60 |
| ▸ | PRKCG | P05129 | 1/20 | 0.60 |
| ▸ | PRKCB | P05771 | 1/20 | 0.60 |
| ▸ | PRKCA | P17252 | 1/20 | 0.60 |
| ▸ | PRKCH | P24723 | 1/20 | 0.60 |
| ▸ | PRKCI | P41743 | 1/20 | 0.60 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29391222 | 1.00 | FGFR1 (0.86) | FGFR1FGFR2FGFR4FGFR3KDR | |
| Hydrochloric Acid SCHEMBL29388307 | 0.99 | FGFR1 (0.84) | FGFR1FGFR2FGFR4FGFR3KDR | |
| Hydrochloric Acid SCHEMBL22531887 | 0.99 | FGFR1 (0.84) | FGFR1FGFR2FGFR4FGFR3KDR | |
| SCHEMBL24490292 | 0.92 | FGFR1 (1.00) | FGFR1FGFR2FGFR4FGFR3KDR | |
| SCHEMBL19601461 | 0.91 | FGFR1 (0.88) | FGFR1FGFR2FGFR4FGFR3KDR | |
| SCHEMBL22532398 | 0.90 | FGFR1 (0.87) | FGFR1FGFR2FGFR4FGFR3KDR | |
| SCHEMBL22532348 | 0.90 | FGFR1 (0.87) | FGFR1FGFR2FGFR4FGFR3KDR | |
| SCHEMBL29388263 | 0.90 | FGFR1 (0.87) | FGFR1FGFR2FGFR4FGFR3KDR | |
| SCHEMBL29391039 | 0.90 | FGFR1 (0.87) | FGFR1FGFR2FGFR4FGFR3KDR | |
| SCHEMBL22532497 | 0.88 | FGFR1 (0.84) | FGFR1FGFR2FGFR4FGFR3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220175722-A1 | DEGRADERS OF FIBROBLAST GROWTH FACTOR RECEPTOR 2 (FGFR2) | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-06-09 | — | — | US | disclosed |
| US-20220175722-A1 | DEGRADERS OF FIBROBLAST GROWTH FACTOR RECEPTOR 2 (FGFR2) | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-06-09 | — | — | US | disclosed |
| EP-3952863-A1 | DEGRADERS OF FIBROBLAST GROWTH FACTOR RECEPTOR 2 (FGFR2) | Dana-Farber Cancer Institute, Inc. (US) | 2022-02-16 | — | — | EP | disclosed |
| WO-2020210451-A1 | DEGRADERS OF FIBROBLAST GROWTH FACTOR RECEPTOR 2 (FGFR2) | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-10-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220175722-A1 | DEGRADERS OF FIBROBLAST GROWTH FACTOR RECEPTOR 2 (FGFR2) | FGFR2, FGF2, FGFR1 | FGFR1 3/4885FGFR2 1/4885FGFR4 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.