Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 4/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 3/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.38 |
| ▸ | NQO1 | P15559 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22823034 | 0.89 | DPP4 (0.38) | DPP4PDE3BPDE3AKDM4EATM | |
| SCHEMBL22823351 | 0.86 | DPP4 (0.40) | DPP4PDE3BPDE3AKDM4EATM | |
| SCHEMBL22535971 | 0.80 | DPP4 (0.33) | DPP4PDE3BPDE3AKDM4EATM | |
| SCHEMBL28963207 | 0.77 | PDE3B (0.58) | PDE3BPDE3AKDM4ECYP3A4MAPT | |
| SCHEMBL16740923 | 0.76 | PDE3B (0.74) | PDE3BPDE3A | |
| Hydrochloric Acid SCHEMBL18128185 | 0.75 | PDE3B (0.72) | PDE3BPDE3A | |
| SCHEMBL22535996 | 0.75 | PDE3B (0.43) | PDE3BPDE3AKDM4ECYP3A4MAPT | |
| SCHEMBL22823350 | 0.74 | DPP4 (0.30) | DPP4 | |
| SCHEMBL1711296 | 0.74 | CYP3A4 (0.53) | PDE3BPDE3AKDM4ECYP3A4MAPT | |
| SCHEMBL29368836 | 0.74 | CYP3A4 (0.53) | PDE3BPDE3AKDM4ECYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118084813-A | Macrocyclic compounds | 诺和诺德牛津研究中心有限公司 | 2024-05-28 | — | — | CN | disclosed |
| CN-110691777-B | Macrocyclic compounds | 诺和诺德牛津研究中心有限公司 | 2024-03-01 | — | — | CN | disclosed |
| US-20230365514-A1 | MACROCYCLIC COMPOUNDS | NOVO NORDISK RESEARCH CENTRE OXFORD LIMITED (GB) | 2023-11-16 | — | — | US | disclosed |
| US-20230365514-A1 | MACROCYCLIC COMPOUNDS | NOVO NORDISK RESEARCH CENTRE OXFORD LIMITED (GB) | 2023-11-16 | — | — | US | disclosed |
| US-20230365514-A1 | MACROCYCLIC COMPOUNDS | NOVO NORDISK RESEARCH CENTRE OXFORD LIMITED (GB) | 2023-11-16 | — | — | US | disclosed |
| US-20200399232-A1 | MACROCYCLIC COMPOUNDS | ZIYLO LTD (GB) | 2020-12-24 | — | — | US | disclosed |
| US-10800747-B2 | Macrocyclic compounds | ZIYLO LTD (GB) | 2020-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10800747-B2 | Macrocyclic compounds | SLC2A4, GALE, MPI | DPP4 39/4885PDE3B 3237/4885PDE3A 3568/4885 |
| US-20200399232-A1 | MACROCYCLIC COMPOUNDS | SLC2A4, GALE, MPI | DPP4 39/4885PDE3B 3237/4885PDE3A 3568/4885 |
| US-20230365514-A1 | MACROCYCLIC COMPOUNDS | SLC2A4, GALE, MPI | DPP4 39/4885PDE3B 3237/4885PDE3A 3568/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.