Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 3/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 5/20 | 0.40 |
| ▸ | BRAF | P15056 | 5/20 | 0.40 |
| ▸ | KRAS | P01116 | 4/20 | 0.40 |
| ▸ | KDR | P35968 | 4/20 | 0.40 |
| ▸ | MAP2K2 | P36507 | 4/20 | 0.40 |
| ▸ | MAP2K1 | Q02750 | 4/20 | 0.40 |
| ▸ | SRC | P12931 | 4/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.38 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 4/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.36 |
| ▸ | LYN | P07948 | 2/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15000163 | 0.86 | PDGFRA (0.54) | BTKPDGFRAKITRAF1BRAF | |
| Hydrochloric Acid SCHEMBL14999914 | 0.86 | PDGFRA (0.54) | BTKPDGFRAKITRAF1BRAF | |
| SCHEMBL14999793 | 0.84 | SMN1; SMN2 (0.47) | BTKPDGFRAKITRAF1BRAF | |
| SCHEMBL15000077 | 0.82 | KIT (0.64) | BTKPDGFRAKITRAF1BRAF | |
| SCHEMBL14999752 | 0.80 | KIT (0.55) | BTKPDGFRAKITRAF1BRAF | |
| SCHEMBL14999909 | 0.80 | BTK (0.48) | BTKPDGFRAKITRAF1BRAF | |
| Hydrochloric Acid SCHEMBL14999996 | 0.79 | KIT (0.54) | BTKPDGFRAKITRAF1BRAF | |
| SCHEMBL22538076 | 0.79 | BTK (0.40) | BTKPDGFRAKITRAF1BRAF | |
| SCHEMBL22538255 | 0.78 | RAF1 (0.46) | BTKPDGFRAKITRAF1BRAF | |
| SCHEMBL14999816 | 0.78 | KIT (0.52) | BTKPDGFRAKITRAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3722296-A2 | DIHYDRONAPHTHYRIDINES AND RELATED COMPOUNDS USEFUL AS KINASE INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISEASES | Deciphera Pharmaceuticals, LLC (US) | 2020-10-14 | — | — | EP | disclosed |