Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | HTR2C | P28335 | 2/20 | 0.37 |
| ▸ | HTR2B | P41595 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | WEE1 | P30291 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PRKCI | P41743 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13808671 | 1.00 | PIM1 (0.39) | PIM1SIGMAR1HTR2AHTR2CHTR2B | |
| SCHEMBL12916351 | 1.00 | PIM1 (0.39) | PIM1SIGMAR1HTR2AHTR2CHTR2B | |
| SCHEMBL4935360 | 0.84 | PIM1 (0.44) | PIM1SIGMAR1HTR2AHTR2CHTR2B | |
| SCHEMBL4940851 | 0.84 | WEE1 (0.41) | PIM1SIGMAR1HTR2AHTR2CHTR2B | |
| SCHEMBL4939560 | 0.84 | PIM1 (0.38) | PIM1SIGMAR1HTR2AHTR2CHTR2B | |
| SCHEMBL24028089 | 0.84 | PIM1 (0.38) | PIM1SIGMAR1HTR2AHTR2CHTR2B | |
| SCHEMBL16853407 | 0.84 | HDAC1 (0.39) | PIM1SIGMAR1HTR2AHTR2CHTR2B | |
| SCHEMBL4935362 | 0.84 | PIM1 (0.44) | PIM1SIGMAR1HTR2AHTR2CHTR2B | |
| SCHEMBL11019668 | 0.84 | PIM1 (0.38) | PIM1SIGMAR1HTR2AHTR2CHTR2B | |
| SCHEMBL4939564 | 0.84 | PIM1 (0.38) | PIM1SIGMAR1HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4169919-A1 | PYRAZOLO[3,4-D]PYRIMIDINE-3-KETONE DERIVATIVE AS WEE-1 INHIBITOR | Wigen Biomedicine Technology (Shanghai) Co., Ltd. (CN) | 2023-04-26 | — | — | EP | disclosed |
| WO-2020210377-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | NUVATION BIO INC. (US) | 2020-10-15 | — | — | WO | disclosed |
| WO-2020210383-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | NUVATION BIO INC. (US) | 2020-10-15 | — | — | WO | disclosed |