Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 10/20 | 0.51 |
| ▸ | JAK1 | P23458 | 9/20 | 0.51 |
| ▸ | JAK2 | O60674 | 7/20 | 0.51 |
| ▸ | TYK2 | P29597 | 4/20 | 0.51 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.49 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.47 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.43 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.43 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.42 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.42 |
| ▸ | MYLK4 | Q86YV6 | 2/20 | 0.42 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22544640 | 0.81 | JAK3 (0.55) | JAK3JAK1JAK2TYK2LRRK2 | |
| SCHEMBL22544566 | 0.80 | JAK3 (0.51) | JAK3JAK1JAK2TYK2LRRK2 | |
| SCHEMBL31557671 | 0.80 | JAK3 (0.56) | JAK3JAK1JAK2TYK2LRRK2 | |
| SCHEMBL22097675 | 0.80 | JAK3 (0.56) | JAK3JAK1JAK2TYK2LRRK2 | |
| SCHEMBL29754172 | 0.80 | LRRK2 (0.52) | JAK3JAK1JAK2TYK2LRRK2 | |
| SCHEMBL22544819 | 0.80 | LRRK2 (0.52) | JAK3JAK1JAK2TYK2LRRK2 | |
| SCHEMBL15231456 | 0.79 | MAPK1 (0.64) | JAK3JAK1JAK2TYK2MAPK1 | |
| SCHEMBL27059237 | 0.79 | JAK3 (0.55) | JAK3JAK1JAK2TYK2LRRK2 | |
| SCHEMBL27169601 | 0.76 | LRRK2 (0.59) | JAK3JAK1JAK2TYK2LRRK2 | |
| SCHEMBL28605526 | 0.76 | DDR2 (0.52) | JAK3JAK1JAK2TYK2LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020206588-A1 | BENZETHERS AND ANILINES OF PYRAZOLYL-AMINO-PYRIMIDINYL DERIVATIVES, AND COMPOSITIONS AND METHODS THEREOF | LYNK PHARMACEUTICALS CO., LTD. (CN) | 2020-10-15 | — | — | WO | disclosed |