Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 4/20 | 0.43 |
| ▸ | CDK4 | P11802 | 9/20 | 0.42 |
| ▸ | CCND1 | P24385 | 9/20 | 0.42 |
| ▸ | CCND2 | P30279 | 8/20 | 0.42 |
| ▸ | CCND3 | P30281 | 8/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.40 |
| ▸ | CDK2 | P24941 | 3/20 | 0.40 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.40 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.40 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.40 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.40 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | LITAF | Q99732 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28677140 | 0.95 | PIK3CA (0.49) | PIK3CACDK4CCND1CCND2CCND3 | |
| SCHEMBL22566488 | 0.88 | CDK4 (0.46) | PIK3CACDK4CCND1CCND2CCND3 | |
| SCHEMBL22557912 | 0.87 | CDK4 (0.44) | PIK3CACDK4CCND1CCND2CCND3 | |
| SCHEMBL22566485 | 0.84 | PIK3CA (0.40) | PIK3CACDK4CCND1CCND2CCND3 | |
| SCHEMBL23633060 | 0.83 | PIK3CA (0.41) | PIK3CACDK4CCND1CCND2CCND3 | |
| SCHEMBL22566486 | 0.83 | CDK4 (0.58) | PIK3CACDK4CCND1CCND2CCND3 | |
| SCHEMBL22566623 | 0.83 | PIK3CA (0.49) | PIK3CACDK4CCND1CCND2CCND3 | |
| SCHEMBL22553522 | 0.83 | CDK4 (0.41) | PIK3CACDK4CCND1CCND2CCND3 | |
| SCHEMBL22557914 | 0.83 | CDK4 (0.41) | PIK3CACDK4CCND1CCND2CCND3 | |
| SCHEMBL4826130 | 0.81 | CDK4 (0.52) | PIK3CACDK4CCND1CCND2CCND3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114007697-A | Antiproliferative agents for the treatment of PAH | 辉瑞公司 | 2022-02-01 | — | — | CN | disclosed |
| US-11203594-B2 | Anti-proliferative agents for treating PAH | PFIZER INC. (US) | 2021-12-21 | — | — | US | disclosed |
| US-20200331909-A1 | ANTI-PROLIFERATIVE AGENTS FOR TREATING PAH | PFIZER INC. (US) | 2020-10-22 | — | — | US | disclosed |
| WO-2020212865-A1 | ANTI-PROLIFERATIVE AGENTS FOR TREATING PAH | PFIZER INC. (US) | 2020-10-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11203594-B2 | Anti-proliferative agents for treating PAH | EDNRB, EDNRA, PAH | PIK3CA 1541/4885CDK4 219/4885CCND1 108/4885 |
| US-20200331909-A1 | ANTI-PROLIFERATIVE AGENTS FOR TREATING PAH | EDNRB, EDNRA, PAH | PIK3CA 1541/4885CDK4 219/4885CCND1 108/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.