Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 20/20 | 0.81 |
| ▸ | CCND1 | P24385 | 20/20 | 0.81 |
| ▸ | CCND3 | P30281 | 20/20 | 0.81 |
| ▸ | CDK6 | Q00534 | 20/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22553543 | 1.00 | CDK4 (0.81) | CDK4CCND1CCND3CDK6 | |
| SCHEMBL22585506 | 1.00 | CDK4 (0.81) | CDK4CCND1CCND3CDK6 | |
| SCHEMBL22553499 | 0.89 | CDK4 (1.00) | CDK4CCND1CCND3CDK6 | |
| SCHEMBL22553565 | 0.89 | CDK4 (1.00) | CDK4CCND1CCND3CDK6 | |
| SCHEMBL22553582 | 0.89 | CDK4 (1.00) | CDK4CCND1CCND3CDK6 | |
| SCHEMBL22566490 | 0.89 | CDK4 (1.00) | CDK4CCND1CCND3CDK6 | |
| SCHEMBL22585442 | 0.88 | CDK4 (0.79) | CDK4CCND1CCND3CDK6 | |
| SCHEMBL22553610 | 0.88 | CDK4 (0.79) | CDK4CCND1CCND3CDK6 | |
| SCHEMBL22553513 | 0.87 | CDK4 (0.77) | CDK4CCND1CCND3CDK6 | |
| SCHEMBL22553603 | 0.86 | CDK4 (0.78) | CDK4CCND1CCND3CDK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11203594-B2 | Anti-proliferative agents for treating PAH | PFIZER INC. (US) | 2021-12-21 | — | — | US | disclosed |
| US-20200331909-A1 | ANTI-PROLIFERATIVE AGENTS FOR TREATING PAH | PFIZER INC. (US) | 2020-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11203594-B2 | Anti-proliferative agents for treating PAH | EDNRB, EDNRA, PAH | CDK4 219/4885CCND1 108/4885CCND3 143/4885 |
| US-20200331909-A1 | ANTI-PROLIFERATIVE AGENTS FOR TREATING PAH | EDNRB, EDNRA, PAH | CDK4 219/4885CCND1 108/4885CCND3 143/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.