Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18550789 | 0.90 | CHRM2 (0.43) | USP2SMN1; SMN2EPHX2HPGDALDH1A1 | |
| SCHEMBL22556800 | 0.87 | HPGD (0.44) | USP2SMN1; SMN2EPHX2HPGDALDH1A1 | |
| SCHEMBL22556801 | 0.87 | HPGD (0.44) | USP2SMN1; SMN2EPHX2HPGDALDH1A1 | |
| SCHEMBL21852667 | 0.83 | CHRM2 (0.58) | USP2SMN1; SMN2EPHX2HPGDALDH1A1 | |
| SCHEMBL13568032 | 0.83 | CHRM2 (0.58) | USP2SMN1; SMN2EPHX2HPGDALDH1A1 | |
| SCHEMBL24764754 | 0.83 | CHRM2 (0.58) | USP2SMN1; SMN2EPHX2HPGDALDH1A1 | |
| SCHEMBL22565928 | 0.83 | USP2 (0.49) | USP2SMN1; SMN2EPHX2HPGDALDH1A1 | |
| SCHEMBL26766586 | 0.83 | USP2 (0.49) | USP2SMN1; SMN2EPHX2HPGDALDH1A1 | |
| SCHEMBL25273083 | 0.81 | USP2 (0.47) | USP2SMN1; SMN2EPHX2HPGDALDH1A1 | |
| SCHEMBL6976084 | 0.81 | CHRM2 (0.43) | USP2SMN1; SMN2EPHX2HPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111825657-A | Dual-function chimeric heterocyclic compound for targeted degradation of androgen receptor and application thereof | 成都海创药业有限公司 | 2020-10-27 | — | — | CN | disclosed |
| WO-2020211822-A1 | A CLASS OF BIFUNCTIONAL CHIMERIC HETEROCYCLIC COMPOUNDS FOR TARGETED DEGRADATION OF ANDROGEN RECEPTORS AND USE THEREOF | 成都海创药业有限公司 | 2020-10-22 | — | — | WO | disclosed |
| WO-2020211822-A1 | A CLASS OF BIFUNCTIONAL CHIMERIC HETEROCYCLIC COMPOUNDS FOR TARGETED DEGRADATION OF ANDROGEN RECEPTORS AND USE THEREOF | 成都海创药业有限公司 | 2020-10-22 | — | — | WO | disclosed |