Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ERN1 | O75460 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2207311 | 0.84 | HTT (0.50) | KMT2AMEN1PKMHTTMAPT | |
| SCHEMBL29865611 | 0.84 | HTT (0.50) | KMT2AMEN1PKMHTTMAPT | |
| SCHEMBL28563085 | 0.81 | MAPT (0.44) | PKMHTTMAPTGAASMN1; SMN2 | |
| SCHEMBL14831812 | 0.79 | HTT (0.45) | KMT2AMEN1PKMHTTMAPT | |
| SCHEMBL3648669 | 0.76 | ERN1 (0.50) | KMT2AMEN1PKMHTTMAPT | |
| SCHEMBL15081220 | 0.76 | CYP2C19 (0.42) | KMT2AMEN1PKMHTTMAPT | |
| SCHEMBL22556860 | 0.75 | TNFSF11 (0.42) | HTTSMN1; SMN2LMNA | |
| SCHEMBL25254525 | 0.75 | KMT2A (0.43) | KMT2AMEN1PKMHTTMAPT | |
| SCHEMBL30465571 | 0.75 | KMT2A (0.43) | KMT2AMEN1PKMHTTMAPT | |
| SCHEMBL8977448 | 0.74 | HTT (0.58) | KMT2AMEN1PKMHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3956322-A1 | JAK1 SELECTIVE KINASE INHIBITOR | DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD. (CN) | 2022-02-23 | — | — | EP | disclosed |
| WO-2020211839-A1 | JAK1 SELECTIVE KINASE INHIBITOR | DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD. (CN) | 2020-10-22 | — | — | WO | disclosed |