Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | KDM6B | O15054 | 1/20 | 0.55 |
| ▸ | KDM5C | P41229 | 1/20 | 0.55 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.55 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.55 |
| ▸ | PLAU | P00749 | 1/20 | 0.51 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.49 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.48 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.46 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.46 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.46 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 3/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | BCR | P11274 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.46 |
| ▸ | CDK8 | P49336 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7822720 | 0.88 | PLAU (0.61) | PLAUMRGPRX4GABRG2GABRB3GABRA5 | |
| SCHEMBL29141521 | 0.86 | KDM4E (0.57) | KDM4CKDM4EKDM6BKDM5CKDM2A | |
| SCHEMBL22557561 | 0.84 | KDM4C (0.61) | KDM4CKDM4EKDM6BKDM5CKDM2A | |
| SCHEMBL4736456 | 0.82 | CLK4 (0.49) | CLK4ABL1BCRALDH1A1CYP1A2 | |
| SCHEMBL14226723 | 0.82 | CLK4 (0.49) | KDM4CCLK4GRM5CYP1A2CYP3A4 | |
| SCHEMBL14241381 | 0.82 | GSK3B (0.49) | KDM4CCLK4GRM5ALDH1A1CYP1A2 | |
| SCHEMBL2072525 | 0.82 | HDAC2 (0.53) | KDM4EPLAUCLK4GABRG2GABRB3 | |
| SCHEMBL60040 | 0.82 | MRGPRX4 (0.56) | PLAUMRGPRX4GRM5TSHR | |
| SCHEMBL30444713 | 0.82 | MRGPRX4 (0.56) | PLAUMRGPRX4GRM5TSHR | |
| SCHEMBL28493467 | 0.81 | KDM4E (0.60) | KDM4CKDM4EKDM6BKDM5CKDM2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020212351-A1 | SUBSTITUTED CYANOPYRROLIDINES WITH ACTIVITY AS USP30 INHIBITORS | MISSION THERAPEUTICS LIMITED (GB) | 2020-10-22 | — | — | WO | disclosed |