Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 15/20 | 0.78 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.78 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.78 |
| ▸ | LCK | P06239 | 3/20 | 0.71 |
| ▸ | SRC | P12931 | 3/20 | 0.71 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.71 |
| ▸ | EPHB2 | P29323 | 3/20 | 0.71 |
| ▸ | EPHB3 | P54753 | 3/20 | 0.71 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.71 |
| ▸ | NEK6 | Q9HC98 | 2/20 | 0.71 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.71 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.71 |
| ▸ | ROR1 | Q01973 | 3/20 | 0.68 |
| ▸ | CSF1R | P07333 | 2/20 | 0.67 |
| ▸ | ABL2 | P42684 | 2/20 | 0.64 |
| ▸ | GAK | O14976 | 1/20 | 0.64 |
| ▸ | MLNR | O43193 | 1/20 | 0.64 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.64 |
| ▸ | JAK2 | O60674 | 1/20 | 0.64 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22559443 | 0.93 | ABL1 (0.78) | ABL1CYP3A4KCNH2LCKSRC | |
| SCHEMBL18298082 | 0.89 | ABL1 (0.80) | ABL1CYP3A4KCNH2LCKSRC | |
| SCHEMBL31697365 | 0.89 | ABL1 (0.80) | ABL1CYP3A4KCNH2LCKSRC | |
| SCHEMBL22559505 | 0.88 | ABL1 (1.00) | ABL1CYP3A4KCNH2LCKSRC | |
| SCHEMBL12989619 | 0.88 | ABL1 (1.00) | ABL1CYP3A4KCNH2LCKSRC | |
| SCHEMBL589689 | 0.88 | ABL1 (1.00) | ABL1CYP3A4KCNH2LCKSRC | |
| SCHEMBL16644466 | 0.87 | CSF1R (0.75) | ABL1CYP3A4KCNH2LCKSRC | |
| SCHEMBL22559451 | 0.87 | CSF1R (0.70) | ABL1CYP3A4KCNH2LCKSRC | |
| SCHEMBL22559454 | 0.85 | CYP3A4 (1.00) | ABL1CYP3A4KCNH2LCKSRC | |
| SCHEMBL22559453 | 0.85 | CYP3A4 (0.76) | ABL1CYP3A4KCNH2LCKSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020214999-A1 | ABELSON NON-TYROSINE KINASE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | EMORY UNIVERSITY (US) | 2020-10-22 | — | — | WO | disclosed |